Incidence and prevalence of idiopathic pulmonary fibrosis
Incidence and prevalence of idiopathic pulmonary fibrosis
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DOI：
10.1164/rccm.200602-163oc
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发表时间：
2006-10-01
影响因子：
24.7
通讯作者：
Oster, Gerry
中科院分区：
文献类型：
--
作者：
Raghu, Ganesh;Weycker, Derek;Oster, Gerry
理论基础：特发性肺纤维化是一种病因不明的慢性间质性肺疾病，其在美国的流行病学尚未得到很好的描述。目的：评估特发性肺纤维化在美国的年发病率和患病率。方法：利用1996年1月至2000年12月期间的大型医疗保健索赔数据库进行回顾性队列设计。测量和主要结果：根据诊断和程序代码确定特发性肺纤维化患者。使用广泛的病例发现标准，在75岁或以上人群中，流行率估计为每100,000人中有4人，年龄在18岁至34岁之间，至每100,000人中有227.2人；年发病率估计为每100,000人中有1.2至76.4人。按照狭义病例发现标准，流行率从每10万人0.8至64.7人不等；发病率的可比数字为每10万人0.4至27.1人。将这些比率外推到美国总人口中，使用广义标准估计的患病率为42.7/10万(发病率，16.3/10万)；使用狭义标准，患病率估计为14.0/10万(发病率，6.8/10万)。结论：我们的结果表明，特发性肺纤维化在美国可能比以前报道的更常见。
Rationale: Idiopathic pulmonary fibrosis is a chronic interstitial lung disease of unknown etiology; its epidemiology in the United States has not been well characterized.Objective: To estimate the annual incidence and prevalence of idiopathic pulmonary fibrosis in the United States.Methods: Retrospective cohort design utilizing a large health care claims database spanning the period January 1996 through December 2000.Measurements and Main Results: Persons with idiopathic pulmonary fibrosis were identified based on diagnosis and procedure codes. Using broad case-finding criteria, prevalence was estimated to range from 4.0 per 100,000 persons aged 18 to 34 yr to 227.2 per 100,000 among those 75 yr or older; annual incidence was estimated to range from 1.2 to 76.4 per 100,000. Using narrow case-finding criteria, prevalence ranged from 0.8 to 64.7 per 100,000 persons; comparable figures for incidence were 0.4 to 27.1 per 100,000 persons. Extrapolating these rates to the overall United States' population, prevalence was estimated to be 42.7 per 100,000 (incidence, 16.3 per 100,000) using broad criteria; with narrow criteria, prevalence was estimated to be 14.0 per 100,000 (incidence, 6.8 per 100,000).Conclusions: Our results suggest that idiopathic pulmonary fibrosis is probably more common in the United States than previously reported.