Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma
Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma
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DOI：
10.1111/j.1365-2133.2010.10199.x
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发表时间：
2011-05-01
影响因子：
10.3
通讯作者：
Ono, M.
中科院分区：
文献类型：
--
作者：
Fujii, H.;Arakawa, A.;Ono, M.
P>背景中型先天性黑素细胞痣 (CMN) 的治疗具有挑战性。目的介绍二氧化碳 (CO2) 和色素特异性激光治疗 55 CMN 的结果。方法采用 CO2 和调Q 激光（倍频 Nd:YAG、Nd:YAG 和紫翠玉）治疗 55 CMN。患者每隔 3 个月接受一次治疗，直至达到最大清除率。最终治疗后 3-6 个月的临床反应分为差（< 50%）、好（50-75%）或极好（> 75%）。通过病例记录审查和问卷调查来评估结果。结果 55 个 CMN 中，36 个为黄斑，19 个为乳牙。头部和颈部有 27 个 CMN。对于黄斑 CMN，躯干 CMN 的结果更好。在用 CO2 激光治疗的三个下肢黄斑 CMN 中发现疤痕和苍白。头部和颈部的乳腺 CMN 表现出最大的改善。颜料专用激光没有额外的好处。 6% 的黄斑和 21% 的乳状 CMN 发生重新色素沉着。 46%的患者报告了部分或完全的CMN治疗。结论与黄斑CMN相比，乳腺CMN对激光治疗的反应略好。四肢CMN反应较差。色素特异性激光不会减轻乳突状 CMN。 CO2 激光治疗下肢黄斑 CMN 可能会出现不良反应。
P>BackgroundTreatment of medium-sized congenital melanocytic naevi (CMN) can be challenging.ObjectivesTo present the results of treatment of 55 CMN with the carbon dioxide (CO2) and pigment-specific lasers.MethodsCO2 and Q-switched lasers (frequency-doubled Nd:YAG, Nd:YAG and alexandrite) were used to treat 55 CMN. Patients were treated at 3-month intervals until maximum clearance. Clinical response at 3-6 months after final treatment was graded as poor (< 50%), good (50-75%) or excellent (> 75%). Outcomes were evaluated on case note review and questionnaire.ResultsThirty-six of the 55 CMN were macular and 19 were mammillated. Twenty-seven CMN were present on the head and neck. For macular CMN, outcomes were better for truncal CMN. Scarring and pallor were seen in three lower limb macular CMN treated with a CO2 laser. Mammillated CMN on the head and neck showed most improvement. Pigment-specific lasers were of no additional benefit. Repigmentation occurred in 6% of macular and 21% of mammillated CMN. Partial or complete regimentation of CMN was reported by 46% of patients.ConclusionsCompared with macular CMN, mammillated CMN show a marginally better response to laser treatment. CMN on the limbs respond poorly. Pigment-specific lasers do not lighten mammillated CMN. Adverse effects can occur with CO2 laser treatment of macular CMN on lower limbs.