Nanomechanical strength mechanisms of hierarchical biological materials and tissues
Nanomechanical strength mechanisms of hierarchical biological materials and tissues
复制标题
DOI：
10.1080/10255840802078030
复制
发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Ackbarow, Theodor
中科院分区：
文献类型：
--
作者：
Buehler, Markus J.;Ackbarow, Theodor
生物蛋白质材料（BPM）是由化学构件组装而成的有趣的等级结构，对生命的关键功能至关重要。BPM的结构细节是迷人的：它们代表了普遍发现的基序（如-螺旋或-片）与高度适应的蛋白质结构（如细胞骨架网络或蜘蛛丝纳米复合材料）的组合。BPM结合了联合收割机的性能，如强度和坚固性，自我修复能力，适应性，可变性，进化性和其他多功能材料在合成材料中无与伦比的水平。实现这些特性的能力关键取决于这些材料的特定特性，首先是它们的分层结构以及从纳米到宏观的材料和结构的无缝集成。在这里，我们提供了一个简短的回顾这一领域，并概述了新的研究方向，沿着的审查最近的研究成果，在发展中的生物蛋白质材料的结构-性能关系的波形蛋白中间丝的研究为例。
Biological protein materials (BPMs), intriguing hierarchical structures formed by assembly of chemical building blocks, are crucial for critical functions of life. The structural details of BPMs are fascinating: They represent a combination of universally found motifs such as -helices or -sheets with highly adapted protein structures such as cytoskeletal networks or spider silk nanocomposites. BPMs combine properties like strength and robustness, self-healing ability, adaptability, changeability, evolvability and others into multi-functional materials at a level unmatched in synthetic materials. The ability to achieve these properties depends critically on the particular traits of these materials, first and foremost their hierarchical architecture and seamless integration of material and structure, from nano to macro. Here, we provide a brief review of this field and outline new research directions, along with a review of recent research results in the development of structure-property relationships of biological protein materials exemplified in a study of vimentin intermediate filaments.