Nocturnal adrenocorticotropin and cortisol secretion depends on sleep duration and decreases in association with spontaneous awakening in the morning.
Nocturnal adrenocorticotropin and cortisol secretion depends on sleep duration and decreases in association with spontaneous awakening in the morning.
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夜间促肾上腺皮质激素和皮质醇的分泌取决于睡眠持续时间，并随着早晨自发觉醒而减少。
DOI：
10.1210/jcem.75.6.1334495
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
J. Born
中科院分区：
文献类型：
--
作者：
E. Späth;T. Schöller;W. Kern;H. Fehm;J. Born
下丘脑-垂体-肾上腺皮质系统的夜间活动在多大程度上取决于睡眠和早晨的觉醒，这一点仍然存在争议。因此，我们调查了14名健康男性受试者（2300 h和1100 h之间）血浆ACTH和皮质醇水平与夜间睡眠和自发觉醒的关系。在入睡至入睡后476.9分钟之间，平均血浆皮质醇水平显著高于入睡前，（P < 0.01）高（210 +/- 15 vs. 155 +/- 9 nmol/L）（476.9 +/- 15.0分钟; n = 7;平均值+/- SEM）比总睡眠时间更长的组（596.9 +/- 14.4分钟; n = 7）。早晨的自发觉醒与任何特定睡眠阶段的存在或血浆ACTH和皮质醇水平的升高无关。然而，自发觉醒后，血浆促肾上腺皮质激素和皮质醇在两组短暂上升。此后，在清醒期间血浆ACTH和皮质醇突然下降，在所有科目的觉醒时间无关。血浆ACTH和皮质醇曲线的斜率在觉醒后（直到1100小时）与觉醒前相同时间间隔之间存在显著差异（ACTH：P <0.001;皮质醇：P < 0.002，所有受试者）。我们的结论是，睡眠时间和夜间ACTH和皮质醇的分泌是相互关联的。此外，这些数据表明，下丘脑-垂体-肾上腺皮质系统的内源性清晨激活是由与觉醒密切相关的机制终止的。
It is still discussed controversially to what extent the nocturnal activity of the hypothalamus-pituitary-adrenocortical system depends on sleep and awakening in the morning. Therefore, we investigated the association of plasma ACTH and cortisol levels with undisturbed nocturnal sleep and spontaneous awakening in 14 healthy male subjects (between 2300 h and 1100 h). Between sleep onset and 476.9 min after sleep onset mean plasma cortisol level was significantly (P < 0.01) higher (210 +/- 15 vs. 155 +/- 9 nmol/L) in the group with a shorter (476.9 +/- 15.0 min; n = 7; mean +/- SEM) than in the group with a longer total sleep time (596.9 +/- 14.4 min; n = 7). Spontaneous awakening in the morning was not linked to the presence of any specific sleep stage or to rising plasma ACTH and cortisol levels. However, spontaneous awakening was followed by a brief rise in plasma ACTH and cortisol in both groups. Thereafter, during wakefulness plasma ACTH and cortisol abruptly declined in all subjects irrespective of the time of awakening. The slope of the plasma ACTH and cortisol curves differed significantly (ACTH: P < 0.001; cortisol: P < 0.002, for all subjects) comparing the time after awakening (until 1100 h) with a time interval of identical length before awakening. We conclude that the duration of sleep and nocturnal ACTH and cortisol secretion are interrelated. Furthermore, the data suggest that the endogenous early morning activation of the hypothalamus-pituitary-adrenocortical system is terminated by mechanisms closely associated with awakening.