Time-dependent changes in prostaglandin excretion in response to frusemide in man.
Time-dependent changes in prostaglandin excretion in response to frusemide in man.
复制标题
人类对呋塞米的反应中前列腺素排泄的时间依赖性变化。
DOI：
10.1042/cs0560077
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发表时间：
1979
期刊：
影响因子：
6
通讯作者：
P. Weber
中科院分区：
文献类型：
--
作者：
B. Scherer;P. Weber
1.为了通过非侵入性技术评价前列腺素（PG）化合物在速尿给药后初始肾脏血液动力学效应中的可能作用，我们研究了静脉注射该药前、15 min和120 min时PGE2和PGF2 α的尿排泄。2.速尿后15分钟内，所有19名志愿者的前列腺素E2和前列腺素F2 α排泄量增加，PG排泄量在120分钟时恢复到对照值。速尿对前列腺素F2 α排泄的刺激在男性中明显低于女性，但这种差异在统计学上不显著。3.研究期间，未发现尿PG化合物与尿量、尿钠和尿钾之间存在明确的关系。4.这些结果支持了以下假设，即速尿后尿PG化合物的快速增加，与肾脏血液动力学的变化平行，可能是PG系统部分或主要在血管室中激活的指标。
1. To evaluate in man by a non-invasive technique the possible role of prostaglandin (PG) compounds in initial renal haemodynamic effects after frusemide we studied the urinary excretion of PGE2 and of PGF2 alpha before and at 15 min and 120 min after intravenous injection of this drug. 2. An increase of PGE2 and of PGF2 alpha excretion was found in all 19 volunteer subjects within 15 min after frusemide, and PG excretion had returned towards control values at 120 min. The stimulation of PGF2 alpha excretion by frusemide was markedly lower in men than in women, but this difference was statistically not significant. 3. No clear-cut relation was found between urinary PG compounds, on the one hand, and urinary volume, urinary sodium and urinary potassium, on the other hand, during the study. 4. The results support the assumption that the rapid increase of urinary PG compounds after frusemide, which parallels the changes in renal haemodynamics, may be an indicator of an activation of the PG system, in part or predominantly, in the vascular compartment.