DISTRIBUTION OF RIBOSOMAL GENE LENGTH VARIANTS AMONG MOUSE CHROMOSOMES
DISTRIBUTION OF RIBOSOMAL GENE LENGTH VARIANTS AMONG MOUSE CHROMOSOMES
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DOI：
10.1073/pnas.79.15.4677
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
EICHER, EM
中科院分区：
文献类型：
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作者：
ARNHEIM, N;TRECO, D;EICHER, EM
The ribosomal genes (rDNA) in mouse inbred strains have a multichromosomal distribution. Using a structural feature of rDNA [variable length rDNA segment (VrDNA)] that shows length polymorphism within and among inbred strains, the chromosomal distribution of the variant ribosomal gene types were studied through genetic analysis. Five of the length variant classes can be divided into 3 discrete linkage groups. The variants present on a particular chromosome pair appear to be unique to that pair and absent from nonhomologous chromosomes. The chromosomal location of particular variants appears to be the same in 2 unrelated inbred strains suggesting that the observed linkage patterns predate the origin of inbred mice. The nonrandom chromosomal distrubition of these rDNA classes suggests that only a limited degree of genetic exchange occurs among nucleolus organizer regions on nonhomologous chromosomes. One particular VrDNA linkage group was localized to chromosome 12. These and other restriction fragment polymorphisms can be used in the construction of detailed mouse linkage maps.
