Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome.
Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome.
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DOI：
10.1016/j.nicl.2015.09.001
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Mizuno K;Tanaka M;Tanabe HC;Joudoi T;Kawatani J;Shigihara Y;Tomoda A;Miike T;Imai-Matsumura K;Sadato N;Watanabe Y
患有儿童慢性疲劳综合症(CCFS)的患者注意力分散能力下降。我们使用双重言语任务进行了一项研究，以评估注意资源对两种同时活动(挑选元音和阅读故事理解)和功能磁共振成像的分配。患者表现出更大的激活区域，招募更多的额叶区域。CCFS患者的右侧额中回(MFG)在单任务和双任务中均被特异性激活，这一激活水平与任务的动机分数和故事理解的准确性呈正相关。此外，患者的背侧前扣带回(DACC)和左侧MFG仅在双重任务中被激活，且dACC和左侧MFG的激活水平分别与动机和疲劳分数呈正相关。CCFS患者表现出与注意资源相关的更广泛的额叶激活区域，以增加他们在大量心理努力下较差的任务表现。就能源需求而言，这可能效率较低，成本也较高。这似乎与CCFS患者的病理生理学有关，并导致疲劳进一步加剧的恶性循环。注意力分散的减少与儿童和青春期的疲劳有关。健康学生在言语分离注意任务中左侧额叶皮质被激活，CCFS患者右侧MFG和ACG被激活。CCFS在额叶皮质是一种能量低效的过程。
The ability to divide one's attention deteriorates in patients with childhood chronic fatigue syndrome (CCFS). We conducted a study using a dual verbal task to assess allocation of attentional resources to two simultaneous activities (picking out vowels and reading for story comprehension) and functional magnetic resonance imaging. Patients exhibited a much larger area of activation, recruiting additional frontal areas. The right middle frontal gyrus (MFG), which is included in the dorsolateral prefrontal cortex, of CCFS patients was specifically activated in both the single and dual tasks; this activation level was positively correlated with motivation scores for the tasks and accuracy of story comprehension. In addition, in patients, the dorsal anterior cingulate gyrus (dACC) and left MFG were activated only in the dual task, and activation levels of the dACC and left MFG were positively associated with the motivation and fatigue scores, respectively. Patients with CCFS exhibited a wider area of activated frontal regions related to attentional resources in order to increase their poorer task performance with massive mental effort. This is likely to be less efficient and costly in terms of energy requirements. It seems to be related to the pathophysiology of patients with CCFS and to cause a vicious cycle of further increases in fatigue. Decrease in divided attention was related to fatigue in childhood and adolescence. Left frontal cortex of healthy students activated in verbal divided attention task Right MFG and ACG were additionally activated in CCFS patients. CCFS is characterized as an energy-inefficient process in frontal cortex.