Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis
Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis
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DOI：
10.1136/jnnp-2017-315795
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发表时间：
2017-12-01
影响因子：
11
通讯作者：
Dupuis, Luc
中科院分区：
文献类型：
--
作者：
Gorges, Martin;Vercruysse, Pauline;Dupuis, Luc
目的研究肌萎缩侧索硬化症(ALS)患者包括ALS突变携带者和症状前ALS突变携带者的下丘脑体积。方法对251例散发性ALS患者、19例症状ALS突变携带者和32例症状前ALS突变携带者和112例健康对照的高分辨率三维T1加权MRI资料进行分析。下丘脑的体积，无论是总的还是细分的，都被正常化为颅内体积，并根据年龄进行调整。进行与临床和代谢结果的相关性分析。结果散发性ALS患者下丘脑严重萎缩(-21.8%，P<0.05)。
Objective Our objective was to study the hypothalamic volume in a cohort of patients with amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS mutation carriers.Methods High-resolution three-dimensional T1-weighted MRI datasets from 251 patients with sporadic ALS, 19 symptomatic and 32 presymptomatic ALS mutation carriers and 112 healthy controls (HC) were retrospectivally registered for manual delineation of the hypothalamus. The volume of the hypothalamus, in total or subdivided, was normalised to the intracranial volume and adjusted to age. Correlation analyses were performed with clinical and metabolic outcomes. Pathologically defined ALS stages were determined in vivo by diffusion tensor imaging (DTI).Results We observed a severe atrophy of the hypothalamus both in patients with sporadic ALS (-21.8%, p