Co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the united states - Results from the national epidemiologic survey on alcohol and related conditions
Co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the united states - Results from the national epidemiologic survey on alcohol and related conditions
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DOI：
10.1001/archpsyc.61.4.361
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发表时间：
2004-04-01
影响因子：
--
通讯作者：
Pickering, RP
中科院分区：
文献类型：
--
作者：
Grant, BF;Stinson, FS;Pickering, RP
背景：关于美国人群中不同人格障碍（pd）与酒精和药物使用障碍共同发生的信息很少。目的：介绍《精神障碍诊断与统计手册》第四版（DSM-IV）酒精和药物使用障碍以及DSM-IV中10种pd中的7种共现性的国家性别差异数据。设计：在2002 - 2002年全国酒精及相关疾病流行病学调查中进行面对面访谈（N=43093）。地理位置：美国和哥伦比亚特区，包括阿拉斯加和夏威夷。参与者：18岁及以上的家庭和团体居民。结果：在当前有酒精使用障碍的个体中，28.6%（95%置信区间[CI]， 26.7-30.6）至少有1种PD，而47.7% （95% Cl, 43.951.6）的当前有药物使用障碍的个体至少有1种PD。此外，16.4% （95% Cl, 15.1-17.6）至少患有I型PD的个体目前有酒精使用障碍，6.5% （95% Cl, 5.7-7.3）目前有药物使用障碍。pd与酒精和药物使用障碍之间的相关性是压倒性的正相关和显著的（P < 0.05）。总体而言，酒精使用障碍与反社会（比值比[OR]， 4.8; 95% Cl, 4.1-5.6）、戏剧性（OR, 4.7; 95% Cl, 3.8-5.8）和依赖性（OR, 3.0; 95% Cl, 1.9-4.8） pd的关系最为密切。药物使用障碍还与反社会（OR, 11.8; 95% Cl, 9.7-14.3）、表演性（OR, 8.0; 95% Cl, 6.0-10.7）和依赖性（OR, 11.6; 95% Cl, 7.119）高度相关。1) PDs。强迫型、戏剧型、精神分裂型和反社会型PD与特定酒精和药物使用障碍之间的相关性在女性中显著强于男性（P < .04），而依赖型PD与药物依赖之间的相关性在男性中显著强于女性（P < .04）。结论：pd合并酒精和药物使用障碍在美国人群中普遍存在。结果强调需要进一步研究这些疾病的潜在结构以及这些疾病合并症时的治疗意义。
Background: Very little information is available on the co-occurrence of different personality disorders (PDs) and alcohol and drug use disorders in the US population.Objective: To present national data on sex differences in the co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol and drug use disorders and 7 of the 10 DSM-IV PDs.Design: Face-to-face interviews conducted in the 200 1 2002 National Epidemiologic Survey on Alcohol and Related Conditions (N=43093).Setting: The United States and the District of Columbia, including Alaska and Hawaii.Participants: Household and group-quarters residents, aged 18 years and older.Results: Among individuals with a current alcohol use disorder, 28.6% (95% confidence interval [CI], 26.7-30.6) had at least 1 PD, whereas 47.7% (95% Cl, 43.951.6) of those with a current drug use disorder had at least I PD. Further 16.4% (95% Cl, 15.1-17.6) of individuals with at least I PD had a current alcohol use disorder and 6.5% (95% Cl, 5.7-7.3) had a current drug use disorder. Associations between PDs and alcohol and drug use disorders were overwhelmingly positive and significant (P < .05). Overall, alcohol use disorders were most strongly related to antisocial (odds ratio [ OR], 4.8; 95% Cl, 4.1-5.6), histrionic (OR, 4.7; 95% Cl, 3.8-5.8), and dependent (OR, 3.0; 95% Cl, 1.9-4.8) PDs. Drug use disorders also were more highly associated with antisocial (OR, 11.8; 95% Cl, 9.7-14.3), histrionic (OR, 8.0; 95% Cl, 6.0-10.7), and dependent (OR, 11.6; 95% Cl, 7.119. 1) PDs. Associations between obsessive-compulsive, histrionic, schizoid, and antisocial PDs and specific alcohol and drug use disorders were significantly stronger (P < .04) among women than men, whereas the association between dependent PD and drug dependence was significantly greater (P < .04) among men than women.Conclusions: The co-occurrence of PDs with alcohol and drug use disorders is pervasive in the US population. Results highlight the need for further research on the underlying structure of these disorders and the treatment implications of these disorders when comorbid.