The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance Are Independent of IL28B in the Chinese Population.
The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance Are Independent of IL28B in the Chinese Population.
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中国人群中 HLA-A02:01 和 DRB111:01 与丙型肝炎病毒自然清除的关联与 IL28B 无关
DOI：
10.1038/srep31485
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发表时间：
2016-08-11
影响因子：
4.6
通讯作者：
Fu Y
中科院分区：
文献类型：
--
作者：
Huang J;Huang K;Xu R;Wang M;Liao Q;Xiong H;Li C;Tang X;Shan Z;Zhang M;Rong X;Nelson K;Fu Y
10-40%的感染会自发清除丙型肝炎病毒（HCV）。特异性人类白细胞抗原（HLA）等位基因已被确定与HCV清除。然而，在中国人群中，HLA与HCV自发清除相关的数据很少。在本研究中，我们研究了231例自发清除HCV感染的中国自愿献血者与429例慢性HCV感染者的HLA I类和II类基因。我们还研究了他们的IL 28 B SNP（rs 8099917）基因型，因为许多研究者已经发现IL 28 B与自发或治疗诱导的HCV清除密切相关。经Bonferroni校正后，发现HLA-A*02：01和DQB 1 *05：02在两组间的分布存在差异（比值比[OR]分别为1.839，Pc = 0.024和0.547，Pc = 0.016）。多因素Logistic回归分析显示，A*02：01和DRB 1 *11：01（OR分别为1.798，P = 0.008和1.921，P = 0.005）与HCV自发清除率相关，与年龄、性别和IL 28 B基因多态性无关。结论：在中国人群中，HLA-A*02：01和DRB 1 *11：01可能与宿主清除HCV的能力相关，而不依赖于IL 28 B，提示先天性免疫和获得性免疫在HCV的控制中均起重要作用。
Spontaneous clearance of hepatitis C virus (HCV) occurs in 10–40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current study we studied the HLA class I and class II genes in 231 Chinese voluntary blood donors who had cleared HCV infection spontaneously compared to 429 subjects with chronic HCV infections. We also studied their IL28B SNP (rs8099917) genotype, since a number of investigators have found a strong association of IL28B with spontaneous or treatment induced HCV clearance. We found that HLA-A*02:01 and DQB1*05:02 distributed differently between the two groups after Bonferroni correction (odds ratio [OR] = 1.839, Pc = 0.024 and OR = 0.547, Pc = 0.016, respectively). Multivariate logistic regression analysis suggested that A*02:01 and DRB1*11:01 (OR = 1.798, P = 0.008 and OR = 1.921, P = 0.005, respectively) were associated with HCV spontaneous clearance, independent of age, gender and IL28B polymorphism. We concluded that in the Chinese population, HLA-A*02:01 and DRB1*11:01 might be associated with the host capacity to clear HCV independent of IL28B, which suggesting that the innate and adaptive immune responses both play an important role in the control of HCV.