MEATS AND FISH CONSUMED IN THE AMERICAN DIET CONTAIN SUBSTANTIAL AMOUNTS OF ETHER-LINKED PHOSPHOLIPIDS
MEATS AND FISH CONSUMED IN THE AMERICAN DIET CONTAIN SUBSTANTIAL AMOUNTS OF ETHER-LINKED PHOSPHOLIPIDS
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DOI：
10.1093/jn/122.8.1656
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发表时间：
1992-08-01
影响因子：
4.2
通讯作者：
SNYDER, F
中科院分区：
文献类型：
--
作者：
BLANK, ML;CRESS, EA;SNYDER, F
本研究的主要目的是从选定的常用动物源性食品（鲑鱼、鲶鱼、猪肉、牛肉、火鸡和鸡肉）中确定含醚磷脂的含量及其某些多不饱和酰基的浓度。样品中醚连接甘油脂的水平特别令人感兴趣，因为摄入醚脂可以促进血小板活化因子（PAF； 1-烷基-2-乙酰- n-甘油-3-磷酸胆碱）的产生，这是已知最有效的生物介质之一。在所有肉类中都发现了烷基酰-sn-甘油-3-磷酸胆碱，其中猪里脊肉的含量最高（0.9 μ mol/g组织），鸡胸肉的含量最低（0.1 μ mol/g组织）。虽然胆碱缩醛原不像乙醇胺缩醛原那样明显，但在牛肉和火鸡的组织中发现了大量（1.0 μ mol/g组织）的alk-1- enylyl - cn -glycero-3-phosphocholine。三酰基甘油比磷脂含有更大比例的饱和脂肪酸，醚连接的磷脂通常比相同磷脂的二酰基种类更不饱和。我们的数据表明，除了经常食用的动物组织的磷脂部分提供大量的多不饱和脂肪酸外，它们也是醚连接脂质的丰富来源。饲料中的醚连接磷脂可以影响宿主组织的脂质组成，从而影响醚脂质介质产生的生物反应。
The primary goal of this study was to determine the amounts of ether-containing phospholipids, along with their concentration of certain polyunsaturated acyl groups, from selected, commonly consumed foods of animal origin (salmon, catfish, pork, beef, turkey and chicken). Levels of ether-linked glycerolipids in the samples were of particular interest, because ingestion of ether lipids could contribute to the production of platelet-activating factor (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), one of the most potent biological mediators known. Alkylacyl-sn-glycero-3-phosphocholine was found in all of the meats, with pork loin having the highest levels (0.9-mu-mol/g tissue) and chicken breasts the lowest (0.1-mu-mol/g tissue). Although choline plasmalogens were not as evident as the ubiquitous ethanolamine plasmalogens, substantial amounts (1.0-mu-mol/g tissue) of alk-1-enylacyl-sn-glycero-3-phosphocholine were found in tissues from beef and turkey. Triacylglycerols contained greater proportions of saturated fatty acids than phospholipids, and the ether-linked phospholipids were generally more unsaturated than diacyl species of the same phospholipid. Our data indicate that in addition to the phospholipid fraction of commonly eaten animal tissues supplying substantial amounts of polyunsaturated fatty acids, they are also a rich source of ether-linked lipids. Dietary ether-linked phospholipids could influence the lipid composition of host tissues to the extent that biological responses produced by ether lipid mediators would be affected.