Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.
Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.
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DOI：
10.17912/micropub.biology.000695
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发表时间：
2022
影响因子：
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通讯作者：
Tsuruta, Fuminori
中科院分区：
文献类型：
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作者：
Nakamura, Junnosuke;Aihara, Takuma;Chiba, Tomoki;Tsuruta, Fuminori
神经自噬在调节蛋白质质量控制、脑内稳态和体温方面起着重要作用。然而，将自噬缺陷与体温联系起来的机制尚未阐明。在这里，我们报告说，RNA结合基序蛋白3（RBM 3）是一个潜在的候选人，调节体温。我们发现Nestin-Cre ; Atg 7 f/f条件性KO（cKO）小鼠的体温低于野生型（WT）小鼠。此外，RBM 3在Nestin-Cre ; Atg 7 f/f脑中上调。这些数据表明，RBM 3是一个隐含的目标，保持受神经自噬影响的体温。
Neural autophagy plays an important role in regulating protein quality control, brain homeostasis, and body temperature. However, the mechanism that links a defect in autophagy to body temperature has not been elucidated. Here, we report that RNA binding motif protein 3 (RBM3) is a potential candidate that regulates body temperature. We found that the body temperatures of Nestin-Cre ; Atg7 f/f conditional KO (cKO) mice were lower than that of wild-type (WT) mice. Moreover, RBM3 was upregulated in the Nestin-Cre ; Atg7 f/f brain. These data suggest that RBM3 is an implicit target that maintains body temperature influenced by neural autophagy.