Carcinogenicity of some industrial chemical intermediates and solvents.
Carcinogenicity of some industrial chemical intermediates and solvents.
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一些工业化学中间体和溶剂的致癌性。
DOI：
10.1016/s1470-2045(19)30779-x
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
IARCMonographsVol125group
中科院分区：
文献类型：
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作者：
IARCMonographsVol125group
1-溴-3-氯丙烷是生产多种药品、一些农药和其他化学品的中间体。在生产或使用1-溴-3-氯丙烷的工作场所，职业接触是可能的，而普通人群不太可能接触。吸入1-溴-3-氯丙烷可引起雄性和雌性小鼠细支气管肺泡癌、雄性和雌性大鼠肝细胞癌、雌性大鼠肝血管肉瘤和脾单个核细胞白血病的发病。8，9 1-溴-3-氯丙烷改变细胞增殖、细胞死亡或营养供应，在大鼠和小鼠吸入染毒2年后，接触点和远端组织中各种增生性非肿瘤性病变的发生率或严重程度或两者均随剂量增加而增加，包括增生和化生。8、9尽管少数人认为这一证据“有限”，但由于增殖性非肿瘤性病变与良性肿瘤和恶性肿瘤同时被观察到，工作组的共识是，在实验系统中，机械证据是“强有力的”。4-氯三氟苯广泛用作油墨、油漆、色粉和涂料的溶剂和稀释剂，并在汽车工业的分散应用中使用。它也是清洁剂、脱脂剂、污渍去除剂和密封剂等工业和消费配方中的主要成分。一项研究报告了在油漆和汽车制造设施中的职业暴露。10普通民众可能通过消费品和受污染的水和鱼接触。然而，没有测量一般人群暴露的研究可用。4-氯三氟苯诱发的恶性肿瘤
1-Bromo-3-chloropropane is an intermediate in the manufacture of a wide range of pharmaceuticals, some pesticides, and other chemicals. Occupational exposure is possible at workplaces where 1-bromo-3-chloropropane is produced or used, whereas exposure of the general population is unlikely to occur. 1-Bromo-3-chloropropane increased the incidence of malignant neoplasms in both sexes of two species exposed by inhalation, inducing bronchioloalveolar carcinoma in male and female mice, hepatocellular carcinoma in male and female rats, and liver haemangiosarcoma and splenic mononuclear cell leukaemia in female rats. 8, 9 1-Bromo-3-chloropropane alters cell proliferation, cell death, or nutrient supply, with dose-related increases in incidence or severity, or both, of various proliferative nonneoplastic lesions, including both hyperplasia and metaplasia, in pointof-contact and distal tissues following 2-year exposure by inhalation in both sexes of rats and mice. 8, 9 Although a minority view considered this evidence “limited”, as the proliferative non-neoplastic lesions were observed at the same time as benign and malignant tumours, the Working Group consensus was that the mechanistic evidence is “strong” in experimental systems. 4-Chlorobenzotrifluoride is widely used as a solvent and diluent for inks, paints, toners, and coatings and in dispersive applications in the automotive industry. It is also a major component in industrial and consumer formulations such as cleaners, degreasers, stain removers, and sealants. One study reported occupational exposures in paint and vehicle manufacturing facilities. 10 The general population might be exposed via consumer products and contaminated water and fish. However, no studies measuring general population exposure were available. 4-Chlorobenzotrifluoride induced malignant neoplasms