DEPRESSION AND 5HT
DEPRESSION AND 5HT
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DOI：
10.1097/00004850-199112003-00002
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发表时间：
1991-12-01
影响因子：
2.6
通讯作者：
DEAKIN, JFW
中科院分区：
文献类型：
--
作者：
DEAKIN, JFW
多年来，5 HT一直与焦虑和抑郁的机制有关，但证据是相互矛盾的。也许一个错误是认为5 HT是一个单一的系统，而实际上它是高度分化的。关于不同的5 HT受体亚型的知识有爆炸性的增长，并且人们早就知道存在不同的解剖子系统。证据将被总结，不同的系统subserve不同的心理功能和功能障碍，在不同的系统导致抑郁症，焦虑，恐慌和强迫症在一个可以理解的方式。许多证据是兼容的想法，即5 HT系统减少即将发生的或实际的厌恶事件的影响。对令人厌恶的事件的预期与焦虑有关，这激发了回避行为-一种正常的适应性反应。有证据表明，这是由中缝背核和相关的5 HT 2和5 HT 3受体的投射介导的。中缝正中核和相关的5 HT 1A受体的预测似乎介导的反感事件发生后，如果他们持续的弹性。当这个系统崩溃时，抑郁症就会出现。所有有效的抗抑郁药都作用于5 HT 1A，这是恢复力的自然机制。
5HT has been implicated in mechanisms of anxiety and depression for many years but the evidence is contradictory. Perhaps one error has been to think of 5HT as a unitary system when in reality it is highly differentiated. There has been an explosive increase in knowledge about different 5HT receptor subtypes and it has long been known that there are different anatomical subsystems. Evidence will be summarised that the different systems subserve different psychological functions and that dysfunction in the different systems results in depression, anxiety, panic and OCD in an understandable way.Much evidence is compatible with the idea that 5HT systems reduce the impact of impending or actual aversive events. Anticipation of an aversive event is associated with anxiety and this motivates avoidance behaviour-a normal adaptive response. There is evidence that this is mediated by projections of the dorsal raphe nucleus and associated 5HT2 and 5HT3 receptors. Projections of the median raphe nucleus and associated 5HT1A receptors appear to mediate resilience to aversive events once they have occurred or if they persist. When this system breaks down depression results. It will be argued that all effective antidepressants act on 5HT1A, natural mechanisms of resilience.