Organization of the main olfactory bulbs of some mammals: Musk shrews, moles, hedgehogs, tree shrews, bats, mice, and rats
Organization of the main olfactory bulbs of some mammals: Musk shrews, moles, hedgehogs, tree shrews, bats, mice, and rats
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DOI：
10.1002/cne.20004
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发表时间：
2004-04
影响因子：
2.5
通讯作者：
K. Kosaka;T. Kosaka
中科院分区：
文献类型：
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作者：
K. Kosaka;T. Kosaka
我们用化学方法研究了7种哺乳动物的主要嗅球（MOB）的组织，包括鼹鼠、刺猬、树鼩、蝙蝠、小鼠以及实验室麝香鼩和大鼠。我们的研究集中在两点：1）是否nidi，特别是球状突触区域隶属于肾小球，我们以前报道的实验室麝香鼩 MOBs，也存在于其他动物和2）是否房室组织的肾小球和两种类型的肾小球周围细胞，我们提出的大鼠MOBs是普遍的在其他动物。这七个物种之间的一般层状模式是相似的，但离散的巢和巢层被认为只有在两个食虫动物，即鼹鼠和实验室麝香鼩。嗅觉标记蛋白免疫反应（OMP-IR）轴突延伸超出肾小球层（GL）的限制，进入实验室麝香鼠，鼹鼠，刺猬和树鼩的外部丛状层（EPL）或巢层的浅表区域，但不在蝙蝠，小鼠和大鼠。我们观察到，在巢和巢层的鼹鼠和实验室麝香鼩 MOBs，只有少数OMP-IR轴突。在另一种食虫动物刺猬中，从肾小球延伸的OMP-IR突起分散并与GL和EPL之间边界处的钙结合蛋白D28 k-IR细胞混合。在树鼩 MOB的EPL的浅表区域，存在少量微小的肾小球样球状结构，其中从肾小球突出的OMP‐IR轴突与周围钙结合蛋白D28 k ‐IR细胞的树突状分支混合。此外，我们认识到，在我们检查的所有哺乳动物的MOB的肾小球和两种类型的肾小球周围细胞的房室组织。因此，这些结构特征被认为是MOB的共同和重要的组织原则。J. Comp.神经元472：1-12，2004.© 2004 Wiley利斯公司
We immunohistochemically examined the organization of the main olfactory bulbs (MOBs) in seven mammalian species, including moles, hedgehogs, tree shrews, bats, and mice as well as laboratory musk shrews and rats. We focused our investigation on two points: 1) whether nidi, particular spheroidal synaptic regions subjacent to glomeruli, which we previously reported for the laboratory musk shrew MOBs, are also present in other animals and 2) whether the compartmental organization of glomeruli and two types of periglomerular cells we proposed for the rat MOBs are general in other animals. The general laminar pattern was similar among these seven species, but discrete nidi and the nidal layer were recognized only in two insectivores, namely, the mole and laboratory musk shrew. Olfactory marker protein‐immunoreactive (OMP‐IR) axons extended beyond the limits of the glomerular layer (GL) into the superficial region of the external plexiform layer (EPL) or the nidal layer in the laboratory musk shrew, mole, hedgehog, and tree shrew but not in bat, mouse, and rat. We observed, in nidi and the nidal layer in the mole and laboratory musk shrew MOBs, only a few OMP‐IR axons. In the hedgehog, another insectivore, OMP‐IR processes extending from the glomeruli were scattered and intermingled with calbindin D28k‐IR cells at the border between the GL and the EPL. In the superficial region of the EPL of the tree shrew MOBs, there were a small number of tiny glomerulus‐like spheroidal structures where OMP‐IR axons protruding from glomeruli were intermingled with dendritic branches of surrounding calbindin D28k‐IR cells. Furthermore, we recognized the compartmental organization of glomeruli and two types of periglomerular cells in the MOBs of all of the mammals we examined. These structural features are therefore considered to be common and important organizational principles of the MOBs. J. Comp. Neurol. 472:1–12, 2004. © 2004 Wiley‐Liss, Inc.