Urodynamic follow-up of experimental urethral obstruction in individual guinea pigs
Urodynamic follow-up of experimental urethral obstruction in individual guinea pigs
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DOI：
10.1002/nau.1021
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发表时间：
2001-01-01
影响因子：
2
通讯作者：
Nijman, JM
中科院分区：
文献类型：
--
作者：
Wolffenbuttel, KP;Kok, DJ;Nijman, JM
由于尿道梗阻引起的膀胱功能改变是否遵循特定的顺序尚不清楚。为了回答这个问题，我们采用了一个小动物模型，允许重复完整的压力-流量研究，以便对尿道梗阻时膀胱功能的变化进行个体随访。通过在豚鼠尿道周围放置银环来诱导梗阻。在氯胺酮/噻嗪麻醉下重复尿动力学研究。膀胱充液并通过单根耻骨上导管测量膀胱压力。用阴茎周围的超声探头测量尿流率。在连续11周的时间里，每隔1周对个体豚鼠进行膀胱压和尿流率的精确测量。在对照组动物中，尿动力学参数没有明显变化。梗阻组尿道阻力（Plow,ave）在4周后由20 cm H2O升高至35 cm H2O，并维持在该水平。最大流量（Q-ax）由0.17 m增加到0.24 m。2 - 3周后开信用证。此峰后，10 ~ 11周后逐渐降低至低于起始值。最大流量压力（P-Qmax）在6 ~ 7周后由24 ~ 47 cm H2O升高，随后下降。在梗阻的第1至第4周，可以看到不稳定的宫缩。所有的动物都遵循类似的模式序列，但速度不同。我们的动物模型可以对患有尿道梗阻的个体动物进行完整的尿动力学随访。我们观察到尿动力学模式和膀胱功能参数的特定序列变化。Neurourol。中华医学杂志，2001:699-713。(C) 2001 Wiley-Liss, Inc。
It is unknown whether changes in bladder function due to urethral obstruction follow a specific sequence. To answer this, we adapted a small animal model to allow repeated complete pressure-flow studies, enabling individual follow-up of changes in bladder function on urethral obstruction. Obstruction was induced in guinea pigs by placing a silver ring around the urethra. Urodynamic studies were repeated under anesthesia with ketamine/xylazine. Bladders were filled and bladder pressure measured through a single suprapubic catheter. Urine flow rate was measured using an ultrasound probe around the penis. Accurate measurements of bladder pressure and urine flow rates were obtained at 1-week intervals for 11 weeks in individual guinea pigs. In the control animals, the urodynamic parameters did not show significant changes. In the obstructed group, urethral resistance (Plow,ave) increased from 20 to 35 cm H2O after 4 weeks and remained at that level. The maximum flow rate (Q-ax) increased from 0.17 to 0.24 m.L/s after 2 to 3 weeks. After this peak, it gradually decreased to lower than the starting value after 10 to 11 weeks. The pressure at maximum flow rate (P-Qmax) increased from 24 to 47 cm H2O after 6 to 7 weeks and thereafter declined. During weeks 1 through 4 of obstruction, unstable contractions were seen. All animals followed a similar sequence of patterns but at variable rates. Our animal model allows complete urodynamic follow-up of individual animals with urethral obstruction. We observed a specific sequence of changes in urodynamic patterns and parameters of bladder function. Neurourol. Urodynam 20:699-713, 2001. (C) 2001 Wiley-Liss, Inc.