Responses of complement C1q/tumor necrosis factor-related proteins to acute aerobic exercise
Responses of complement C1q/tumor necrosis factor-related proteins to acute aerobic exercise
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DOI：
10.1016/j.cyto.2022.156083
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发表时间：
2022-11-07
期刊：
影响因子：
3.8
通讯作者：
Tanimura, Yuko
中科院分区：
文献类型：
--
作者：
Kon, Michihiro;Tanimura, Yuko
有氧运动是控制代谢紊乱的有效治疗策略。然而，有氧运动改善代谢疾病的机制尚不完全清楚。补体 C1q/肿瘤坏死因子相关蛋白 (CTRP) 1、CTRP3、CTRP5 和 CTRP9 通过腺苷单磷酸激活蛋白激酶信号通路在改善代谢紊乱方面发挥重要作用。在这项研究中，我们研究了急性有氧运动对人类参与者循环 CTRP1、CTRP3、CTRP5 和 CTRP9 水平的影响。八名健康男性，年龄 20.4 +/- 0.2 岁，身高 173.1 +/- 1.7 cm，体重 68.0 +/- 1.8 kg，体重指数 22.7 +/- 0.7 kg/m2，最大摄氧量 (VO2max) 51.3 +/- 2.5 mL/kg/min，以 VO2max 的 75% 进行急性有氧自行车运动。 30 分钟（数据为平均值 +/- 标准误差）。之前采集了血样；紧接着；以及运动后 30 分钟、60 分钟和 120 分钟。测量 CTRP1、CTRP3、CTRP5、CTRP9、肿瘤坏死因子-α (TNF-α) 和胰岛素的血清浓度。 CTRP1 浓度在运动后立即显着升高，并在长达 120 分钟内保持升高状态 (p < 0.01)。 CTRP3浓度在运动后60分钟显着增加（p < 0.05），并且增加趋势持续到运动后至少120分钟（p < 0.01）。 CTRP5、CTRP9、TNF-α 和胰岛素浓度在运动后立即显着增加（分别为 p < 0.05、p < 0.01、p < 0.05 和 p < 0.05），然后又下降。运动后 CTRP1 和 TNF-α 的峰值浓度之间观察到显着相关性 (p < 0.05)；然而，在运动后 CTRP3 和胰岛素的峰值浓度之间没有观察到相关性。这项研究的结果表明，急性有氧运动可能会增强健康成年人 CTRP1、CTRP3、CTRP5 和 CTRP9 的分泌。
Aerobic exercise is an effective therapeutic strategy to manage metabolic disorders. However, the mechanisms of aerobic exercise-induced improvements in metabolic diseases are not completely understood. Complement C1q/ tumor necrosis factor-related protein (CTRP) 1, CTRP3, CTRP5, and CTRP9 have important roles in improving metabolic disorders via the adenosine monophosphate-activated protein kinase signaling pathway. In this study, we investigated the effects of acute aerobic exercise on circulating CTRP1, CTRP3, CTRP5, and CTRP9 levels in human participants. Eight healthy males with an age of 20.4 +/- 0.2 years, height 173.1 +/- 1.7 cm, body mass 68.0 +/- 1.8 kg, body mass index 22.7 +/- 0.7 kg/m2, and maximal oxygen uptake (VO2max) 51.3 +/- 2.5 mL/kg/min performed acute aerobic cycling exercise at 75 % of their VO2max for 30 min (data are mean +/- standard error). Blood samples were obtained before; immediately after; and 30, 60, and 120 min after exercising. Serum con-centrations of CTRP1, CTRP3, CTRP5, CTRP9, tumor necrosis factor-alpha (TNF-alpha), and insulin were measured. The CTRP1 concentration significantly increased immediately after exercising and remained elevated for up to 120 min (p < 0.01). The CTRP3 concentration significantly increased at 60 min after exercise (p < 0.05), and the increasing trend continued until at least 120 min after exercise (p < 0.01). The CTRP5, CTRP9, TNF-alpha, and insulin concentrations significantly increased immediately after exercise (p < 0.05, p < 0.01, p < 0.05, and p < 0.05, respectively) and decreased thereafter. A significant correlation was observed between the peak post-exercise concentrations of CTRP1 and TNF-alpha (p < 0.05); however, no correlation was observed between the peak post-exercise concentrations of CTRP3 and insulin. The results of this study indicate that acute aerobic exercise may enhance the secretion of CTRP1, CTRP3, CTRP5, and CTRP9 in healthy adults.