Shedding some light on the etiology of adenocarcinomas of the esophagus and gastric cardia.
Shedding some light on the etiology of adenocarcinomas of the esophagus and gastric cardia.
复制标题
揭示食管和贲门腺癌的病因学。
DOI：
10.1038/ajg.2012.337
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Rubenstein,JoelH
中科院分区：
文献类型：
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作者：
Rubenstein,JoelH
环境和行为因素可能在食道和胃食道交界部腺癌的病因中起着重要作用。先前的生态分析表明，暴露在紫外线辐射下对这些癌症具有保护作用。但这样的分析容易产生特定形式的偏见。在这一期的《美国胃肠病学杂志》中，新的个体水平的数据支持了这种联系。据推测，这是由维生素D介导的，但缺乏确凿的证据。目前还不能推荐补充维生素D以预防这些癌症。关于维生素D在Barrett‘s食道和这些癌症中的作用，还需要更多的研究。
Environmental and behavioral factors likely have large roles in the etiology of adenocarcinomas of the esophagus and gastroesophageal junction. Prior ecological analyses suggest a protective effect of exposure to UV radiation for these cancers. But such analyses are prone to particular forms of bias. In this issue ofThe American Journal of Gastroenterology, new individual-level data is presented supporting such an association. Presumably, this is mediated by vitamin D, but definitive evidence is lacking. Supplementation with vitamin D aimed at preventing these cancers cannot be recommended at this time. More study regarding the role of vitamin D in Barrett's esophagus and these cancers are needed.