Daily variation in an intensity of kaolin-induced writhing reaction in mice.
Daily variation in an intensity of kaolin-induced writhing reaction in mice.
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高岭土引起的小鼠扭体反应强度的每日变化。
DOI：
10.1016/s0024-3205(97)00670-x
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发表时间：
1997
期刊：
影响因子：
6.1
通讯作者：
A. Fujimura
中科院分区：
文献类型：
--
作者：
K. Sakamoto;M. Arakawa;M. Ohmori;K. Sugimoto;A. Fujimura
在07：00 - 19：00光照和19：00 - 07：00黑暗条件下饲养的小鼠中检查高岭土诱导的扭体反应强度的每日变化。在00：00、02：00、04：00、06：00、08：00、10：00、12：00、14：00、16：00、18：00、20：00和22：00单次腹腔注射高岭土后，计数30 min的扭体次数。扭体次数呈日变化，高峰在18：00，低谷在06：00。缓激肽B1（Des-Ar g9-[Leu 8]-BK）和缓激肽B2（icatibant）受体拮抗剂预处理可明显减轻扭体反应。在B1拮抗剂组中仍观察到该参数的显著每日变化，但在B2拮抗剂治疗组中消失。结果表明，高岭土诱发的扭体反应具有日变化规律，在安静期结束时出现一个高峰，在活动期结束时出现一个低谷。B2受体介导的刺激似乎参与了这一现象。
The daily variation in an intensity of kaolin-induced writhing reaction was examined in mice kept under conditions of light; 07:00 - 19:00 and dark; 19:00 - 07:00. The number of writhes was counted for 30 minutes after a single intraperitoneal injection of kaolin at 00:00, 02:00, 04:00, 06:00, 08:00, 10:00, 12:00, 14:00, 16:00, 18:00, 20:00 and 22:00. The number of writhes showed a daily variation with a peak at 18:00 and a trough at 06:00. The intensity of writhing reaction was significantly reduced by pretreatment with the bradykinin B1(Des-Ar g9-[Leu8]-BK) and B2(icatibant) receptor antagonists. Significant daily variation in this parameter was still observed in the group with the B1antagonist, but disappeared in the B2antagonist-treated group. These results suggest that the kaolin-induced writhing reaction shows the daily variation with a peak at the end of the resting period and a trough at the end of the active period. The B2receptor mediated stimuli appears to be involved in this phenomenon.