The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies.
The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies.
复制标题
皮质GABA在生命周期中的轨迹，编辑后的MRS研究的个人参与者数据荟萃分析。
DOI：
10.7554/elife.62575
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发表时间：
2021-06-01
期刊：
影响因子：
7.7
通讯作者：
Puts NA
中科院分区：
文献类型：
--
作者：
Porges EC;Jensen G;Foster B;Edden RA;Puts NA
γ-氨基丁酸（GABA）是人脑中主要的抑制性神经递质，可以用磁共振波谱（MRS）测量。研究报告称，在整个生命周期中，大脑皮层GABA水平会降低或升高。这种不相容性可能是这些研究中使用的样本的大小和年龄范围的人为因素。迄今为止，还没有一项研究涵盖了整个生命周期。在这项研究中，八个合适的数据集被整合，以生成一个模型的轨迹额叶GABA估计（通过编辑MRS报告;都表示为比率和机构单位）在整个生命周期。使用对数正态曲线和非参数样条拟合数据，作为使用Stan语言的多水平贝叶斯模型的回归模型。综合数据显示，额叶GABA措施的不对称寿命轨迹涉及早期的增加，随后在成年早期的稳定期，在成年和衰老过程中逐渐减少，以及样条和对数正态模型。所获得的信息将提供一个总体框架，以便根据所研究人口的年龄对未来的研究提出预期。
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts report decreases and increases in cortical GABA levels across the lifespan. This incompatibility may be an artifact of the size and age range of the samples utilized in these studies. No single study to date has included the entire lifespan. In this study, eight suitable datasets were integrated to generate a model of the trajectory of frontal GABA estimates (as reported through edited MRS; both expressed as ratios and in institutional units) across the lifespan. Data were fit using both a log-normal curve and a nonparametric spline as regression models using a multi-level Bayesian model utilizing the Stan language. Integrated data show that an asymmetric lifespan trajectory of frontal GABA measures involves an early period of increase, followed by a period of stability during early adulthood, with a gradual decrease during adulthood and aging that is described well by both spline and log-normal models. The information gained will provide a general framework to inform expectations of future studies based on the age of the population being studied.