Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
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DOI：
10.1002/ptr.1749
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发表时间：
2005-11-01
影响因子：
7.2
通讯作者：
Papageorgiou, VP
中科院分区：
文献类型：
--
作者：
Assimopoulou, AN;Sinakos, Z;Papageorgiou, VP
自由基清除活性涉及衰老过程、衰老、抗癌和伤口愈合活性。因此，在本研究中，具有生物学特性的天然产物，番红花提取物的DPPH自由基清除活性。研究了生长在希腊科扎尼的番红花（Crocos）及其生物活性成分（番红花苷、番红花醛），结果表明，番红花甲醇提取物具有很高的抗氧化活性，尽管它含有几种活性和非活性成分。在试图近似的结构-活性关系，两个生物活性成分的番红花提取物进行了测试，即藏红花素和番红花醛。藏红花素表现出较高的自由基清除活性（500和1000 ppm的甲醇溶液分别为50%和65%），其次是番红花醛（34%，500 ppm的溶液）。所有测试的样品都显示出高的自由基清除活性，可能是由于能够向DPPH自由基提供一个氢原子，因此，生长在希腊的白藜芦醇可以很有希望地用于功能性食品，具有抗氧化活性的饮料，药物和化妆品制剂的抗氧化活性，可能是因为它们的抗衰老活性。藏红花也可以以粉末或其他药理学配方的形式内部使用，作为具有抗氧化特性的食品补充剂。版权所有（c）2005年约翰威利父子有限公司。
Radical scavenging activity is involved in aging processes, antiinflammatory, anticancer and wound healing activity. Hence, in the present study the DPPH radical scavenging activity of a natural product that possesses biological properties, an extract of Crocus sativus L. (saffron), grown in Crocos, Kozani (Greece), and some of its bioactive constituents (crocin, safranal) was studied.It was shown that a methanol extract of Crocus sativus exhibited high antioxidant activity, although it contains several active and inactive constituents. In trying to approximate a structure-activity relationship, two bioactive constituents of saffron extract were tested, namely crocin and safranal. Crocin showed high radical scavenging activity (50% and 65% for 500 and 1000 ppm solution in methanol, respectively), followed by safranal (34% for 500 ppm solution). All the tested samples showed high radical scavenging activity, probably due to the ability to donate a hydrogen atom to the DPPH radical.Thus, saffron grown in Greece can be used promisingly in functional foods, drinks with antioxidant activity, in pharmaceutical and cosmetic preparations for their antioxidant activity and probably for their antiaging activity. Saffron can also be used internally in the form of powder or other pharmacotechnical formulae as a food supplement with antioxidant properties. Copyright (c) 2005 John Wiley & Sons, Ltd.