Mismatch repair defects as a cause of resistance to cytotoxic drugs.
Mismatch repair defects as a cause of resistance to cytotoxic drugs.
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DOI：
10.1586/14737140.1.1.149
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Hall, A G
中科院分区：
文献类型：
--
作者：
Irving, J A;Hall, A G
In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.
