Chiral self-sorting of active semiflexible filaments with intrinsic curvature
Chiral self-sorting of active semiflexible filaments with intrinsic curvature
复制标题
具有固有曲率的活性半柔性细丝的手性自排序
DOI：
10.1039/d0sm01163k
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发表时间：
2021
期刊：
影响因子：
3.4
通讯作者：
Betterton, Meredith D.
中科院分区：
文献类型：
--
作者：
Moore, Jeffrey M.;Glaser, Matthew A.;Betterton, Meredith D.
活性物质系统中的多体相互作用可以导致粒子集体移动并自组织成具有长程有序的动态结构。在细胞中，细胞骨架丝的自组装对于细胞运动、结构、细胞内运输和分裂至关重要。由二维基质（例如细胞皮层）上的聚合或运动蛋白相互作用驱动的半柔性细胞骨架丝可以诱导丝弯曲和曲率，从而导致有趣的集体行为。例如，已知细菌细胞分裂细丝 FtsZ 具有固有曲率，导致其自组织成环和涡旋，并且最近在表面上重建由运动蛋白驱动的微管集体运动的实验观察到，由于运动引起的细丝曲率，集体行为的手性对称性破缺。先前关于驱动细丝系统自组织的工作尚未研究曲率和细丝结构对集体行为的影响。在这项工作中，我们提出了具有固有曲率的驱动半柔性细丝的布朗动力学模拟结果，并研究了细丝刚性和曲率半径之间的相互作用如何调节同手性系统和异手性混合物中的自组织行为。我们发现曲率诱导的从极性簇到自排序手性簇的重组，这是通过细丝灵活性进行修改的。这种转变在长时间尺度上改变了细丝传输从弹道传输到扩散传输。
Many-body interactions in systems of active matter can cause particles to move collectively and self-organize into dynamic structures with long-range order. In cells, the self-assembly of cytoskeletal filaments is critical for cellular motility, structure, intracellular transport, and division. Semiflexible cytoskeletal filaments driven by polymerization or motor-protein interactions on a two-dimensional substrate, such as the cell cortex, can induce filament bending and curvature leading to interesting collective behavior. For example, the bacterial cell-division filament FtsZ is known to have intrinsic curvature that causes it to self-organize into rings and vortices, and recent experiments reconstituting the collective motion of microtubules driven by motor proteins on a surface have observed chiral symmetry breaking of the collective behavior due to motor-induced curvature of the filaments. Previous work on the self-organization of driven filament systems have not studied the effects of curvature and filament structure on collective behavior. In this work, we present Brownian dynamics simulation results of driven semiflexible filaments with intrinsic curvature and investigate how the interplay between filament rigidity and radius of curvature can tune the self-organization behavior in homochiral systems and heterochiral mixtures. We find a curvature-induced reorganization from polar flocks to self-sorted chiral clusters, which is modified by filament flexibility. This transition changes filament transport from ballistic to diffusive at long timescales.