Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: A new access to functionalized enamides
Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: A new access to functionalized enamides
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DOI：
10.1021/ol801534e
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发表时间：
2008-09-04
期刊：
影响因子：
5.2
通讯作者：
Sato, Yoshihiro
中科院分区：
文献类型：
--
作者：
Saito, Nozomi;Katayama, Tomoyuki;Sato, Yoshihiro
本文提出了一种镍催化的多组分偶联反应制备功能化烯酰胺的新方法。偶联反应在镍-IMes催化剂的存在下进行，以高度立体选择性的方式得到相应的γ-甲硅烷基氧基烯酰胺衍生物，其在分子中具有烯丙醇部分。
A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly stereoselective manner.