The structure of diversity within new world mitochondrial DNA haplogroups: Implications for the prehistory of North America
The structure of diversity within new world mitochondrial DNA haplogroups: Implications for the prehistory of North America
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DOI：
10.1086/339690
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发表时间：
2002-04-01
影响因子：
9.8
通讯作者：
Smith, DG
中科院分区：
文献类型：
--
作者：
Malhi, RS;Eshleman, JA;Smith, DG
分析了1,612和395名北美原住民的线粒体DNA单倍群和高变量片段I(HVSI)序列，以确定北美主要的史前种群事件。基因图谱和空间自相关分析表明，单倍群A、B和X频率较高的种群分别在北部、西南部和五大湖区经历了史前种群扩张。单倍型网络显示高水平的网状和高频率的节点单倍型支持这些结果。单倍型网络表明，在单倍群B和C中存在额外的创始谱系；然而，由于HVSI数据集表现出的高度变异性，亚洲和美洲表现出的类似单倍型可能是由于趋同而不是共同祖先。这种高度的变异性和网状结构排除了使用对单倍群内遗传多样性的估计来论证移民到美洲的数量。
The mitochondrial DNA haplogroups and hypervariable segment I (HVSI) sequences of 1,612 and 395 Native North Americans, respectively, were analyzed to identify major prehistoric population events in North America. Gene maps and spatial autocorrelation analyses suggest that populations with high frequencies of haplogroups A, B, and X experienced prehistoric population expansions in the North, Southwest, and Great Lakes region, respectively. Haplotype networks showing high levels of reticulation and high frequencies of nodal haplotypes support these results. The haplotype networks suggest the existence of additional founding lineages within haplogroups B and C; however, because of the hypervariability exhibited by the HVSI data set, similar haplotypes exhibited in Asia and America could be due to convergence rather than common ancestry. The hypervariability and reticulation preclude the use of estimates of genetic diversity within haplogroups to argue for the number of migrations to the Americas.