Shooting for the Moon: Nanoscale Approaches to Cancer.
Shooting for the Moon: Nanoscale Approaches to Cancer.
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DOI：
10.1021/acsnano.6b01095
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发表时间：
2016-02
期刊：
影响因子：
17.1
通讯作者：
P. Hammond
中科院分区：
文献类型：
--
作者：
P. Hammond
to Cancer At President Obama’s 2016 State of the Union address, the President charged Vice President Joseph Biden to lead us on the Moonshot Challenge to address cancer, placing cancer among our country’s top challenges. By putting the spotlight on cancer, the Vice President has become a spokesperson and an advocate for the advances needed to make a meaningful difference in addressing cancer, and provides an opportunity for the public to understand more about the disease and the challenges we face in addressing it. I was fortunate to join the Vice President at a Roundtable Discussion about Moonshot with several other scientists, technologists, and clinicians in the field at the World Economic Forum in Davos, Switzerland just 1 week after the State of the Union charge. At the Roundtable, we discussed key issues that shape this challenge, including the fact that cancer is not a singular disease, but many different diseases, yielding a broad range of responses to specific therapies. There are significant differences in the treatment and projected outcome of, for example, estrogen or progesterone positive breast cancer versus pancreatic or highgrade ovarian cancer. Furthering this complexity is the dynamic nature of the diseasethe fact that constant genetic mutations can lead to cancers that initially present as responsive in a patient, but transform to metastatic and/or recurrent forms that are resistant to the original therapy. Unlike what was needed just prior to our first steps on the moon, the biological understanding, engineering capabilities, and medical knowledge of cancer, though significant enough now to begin our journey, must expand greatly to make a significant dent in cancer.
