TASTE PREFERENCES IN RAT LINES SELECTED FOR LOW AND HIGH ALCOHOL-CONSUMPTION
TASTE PREFERENCES IN RAT LINES SELECTED FOR LOW AND HIGH ALCOHOL-CONSUMPTION
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DOI：
10.1016/0741-8329(92)90027-8
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发表时间：
1992-03-01
期刊：
影响因子：
2.3
通讯作者：
LI, TK
中科院分区：
文献类型：
--
作者：
SINCLAIR, JD;KAMPOVPOLEVOY, A;LI, TK
酒精回避组(ANA)、酒精偏好组(AA)和对照组Wistar大鼠被依次测试了它们对奎宁、糖精、盐和柠檬酸单一浓度溶液的初始偏好，然后是糖精浓度的递增序列。随后对不喜欢酒精(NP)和喜欢酒精(P)的大鼠品系进行了类似的研究。当用单一浓度和递增系列测试时，这两个为低酒精消耗而培育的品系比它们各自为高酒精摄入而培育的品系喝的糖精要少得多。ANA通常也比AAS或Wistar喝更少的苦味、咸味和酸味的溶液，但在其他口味的NP和P之间几乎没有发现差异。糖精消耗与浓度的关系曲线在AAs、Wistars、NPs和Ps的浓度大致相同时达到最大值，但Anas的曲线左移。这一结果支持影响两个品系对酒精和糖精摄入量的遗传因素之间的密切关系。这种关系可能不是由于糖精对老鼠来说尝起来像酒精造成的，因为其他结果表明，NPs最初对酒精的味道没有更多的负面反应，但它可能与类似的机制有关，这些机制介导了甜味和全身酒精的强化。
Alcohol-avoiding (ANA), alcohol-preferring (AA), and control Wistar rats were tested sequentially for their initial preferences for single concentration solutions of quinine, saccharin, salt, and citric acid, and then for an ascending series of saccharin concentrations. A similar study was subsequently conducted with the alcohol-nonpreferring (NP) and alcohol-preferring (P) rat lines. Both lines developed for low alcohol consumption drank much less saccharin than their respective lines developed for high alcohol intake when tested with the single concentration and with the ascending series. The ANAs also generally drank less of the bitter, salty, and sour solutions than the AAs or Wistars but little difference was found between the NPs and Ps with the other tastes. The curve relating saccharin consumption to concentration reached a maximum at about the same concentrations for AAs, Wistars, NPs, and Ps but for the ANAs, was shifted to the left. The results support a close relationship between the genetic factors influencing alcohol and saccharin intake in both line pairs. This relationship is probably not caused by saccharin tasting like alcohol to a rat, because other results indicate that the NPs do not have more negative reactions initially to the taste of alcohol, but it might be related to similar mechanisms mediating the reinforcement from sweet tastes and from systemic alcohol.