Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
复制标题
十八烷氧基乙基 9-[2-(膦酰甲氧基)乙基]鸟嘌呤对 Me-180 人宫颈癌细胞的体外和体内抗增殖作用。
DOI：
10.1159/000292582
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发表时间：
2010
期刊：
影响因子：
3.3
通讯作者：
Hostetler,KarlY
中科院分区：
文献类型：
--
作者：
Valiaeva,Nadejda;Trahan,Julissa;Aldern,KathyA;Beadle,JamesR;Hostetler,KarlY
Background/Aims:9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice.Methods:We synthesized octadecyloxyethyl (ODE) and hexadecyloxypropyl esters of PMEG and compared their antiproliferative activity with unmodified PMEG in primary human fibroblasts and CaSki, Me-180 and HeLa human cervical cancer cell lines in vitro.Results:ODE-PMEG had excellent antiproliferative activity in vitro in this panel of human cervical cancers. We compared the effects of ODE-PMEG and ODE-cidofovir (ODE-CDV) in a solid tumor model using Me-180 human cervical cancer cell lines in athymic nude mice. Intratumoral injection of 25 µg of ODE-PMEG or 100 µg of ODE-CDV daily for 21 days followed by observation for 20–35 days resulted in near-complete disappearance of measurable cervical cancers.Conclusion:ODE-PMEG may be suitable for local or topical treatment of cervical dysplasia.
