On the horizon for fertility preservation in domestic and wild carnivores.
On the horizon for fertility preservation in domestic and wild carnivores.
复制标题
家养和野生食肉动物生育力保存的前景。
DOI：
10.1111/rda.12010
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wildt,DE
中科院分区：
文献类型：
--
作者：
Comizzoli,P;Wildt,DE
ContentsInnovations are emerging from the growing field of fertility preservation for humans and laboratory animals that are relevant to protecting and propagating valuable domestic and wild carnivores. These extend beyond the ‘classical’ approaches associated with sperm, oocyte and embryo freezing to include gonadal tissue preservation combined within vitroculture or xenografting, all of which have potential for rescuing vast amounts of unused and wasted germplasm. Here, we review approaches under development and predicted to have applied value within the next decade, including the following: (i) direct use of early‐stage gametes forin vitrofertilization; (ii) generation of more mature gametes from gonadal tissue or stem cells; (iii) simplification, enhanced safety and efficacy of cryopreservation methods; and (iv) biostabilization of living cells and tissues at ambient temperatures. We believe that all of these fertility preservation strategies will offer knowledge and tools to better manage carnivores that serve as human companions, valuable biomedical models or require assistance to reverse endangerment.
