Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study)
Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study)
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DOI：
10.1016/j.atherosclerosis.2014.07.002
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发表时间：
2014-10-01
期刊：
影响因子：
5.3
通讯作者：
Maerz, Winfried
中科院分区：
文献类型：
--
作者：
Grammer, Tanja B.;Kleber, Marcus E.;Maerz, Winfried
背景：贫血已被证明是冠状动脉疾病和死亡率的危险因素。体内铁储存参与CAD的发展仍然存在争议。到目前为止，研究，同时检查血红蛋白和铁代谢参数doesn 't existence.Methods和结果：血红蛋白和铁的状态确定在1480例稳定的冠状动脉疾病（CAD）和682个人，其中CAD已被排除在血管造影。与最高性别特异性四分位数相比，血红蛋白和铁最低四分位数的CAD多变量校正比值比（OR）分别为1.62（95%CI：1.22-2.16）和2.05（95%CI：1.51-2.78）。与最高性别特异性四分位数相比，转铁蛋白饱和度、铁蛋白（F）和可溶性转铁蛋白受体（sTfR）/log 10 F指数最低四分位数中CAD的完全校正OR分别为1.69（95% CI：1.25-2.27）、1.98（95% CI：1.48-2.65）和1.64（95% CI：1.23-2.18）。当调整铁和铁蛋白时，与最高性别特异性四分位数相比，最低四分位数血红蛋白中CAD的OR仍为1.40（95% CI：1.04-1.90）。因此，铁状态或低血红蛋白与CAD之间的关联似乎彼此独立。sTfR仅与血管造影CAD轻微相关。结论：低血红蛋白和铁缺乏与血管造影CAD独立相关。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist.Methods and results: Hemoglobin and iron status were determined in 1480 patients with stable angiographic coronary artery disease (CAD) and in 682 individuals in whom CAD had been ruled out by angiography. The multivariate adjusted odds ratios (OR) for CAD in the lowest quartiles of hemoglobin and iron were 1.62 (95% CI: 1.22-2.16), and 2.05 (95% CI: 1.51-2.78), respectively compared to their highest gender-specific quartiles. The fully adjusted ORs for CAD in the lowest quartiles of transferrin saturation, ferritin (F) and soluble transferrin receptor (sTfR)/log10F index were 1.69 (95% CI: 1.25-2.27), 1.98 (95% CI: 1.48-2.65), and 1.64 (95% CI: 1.23-2.18), respectively compared to their highest gender-specific quartiles. When adjusting in addition for iron and ferritin the OR for CAD in the lowest quartiles of hemoglobin was still 1.40 (95% CI: 1.04-1.90) compared to the highest gender-specific quartiles. Thus, the associations between either iron status or low hemoglobin and CAD appeared independent from each other. The sTfR was only marginally associated with angiographic CAD.Conclusions: Both low hemoglobin and iron depletion are independently associated with angiographic CAD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.