HUNK Signaling in Metastatic Breast Cancer.
HUNK Signaling in Metastatic Breast Cancer.
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DOI：
10.18632/oncoscience.504
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发表时间：
2020-05-01
期刊：
影响因子：
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通讯作者：
Yeh, Elizabeth
中科院分区：
文献类型：
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作者：
Dilday, Tinslee;Ramos, Nicole;Yeh, Elizabeth
一旦发生转移性疾病，就无法治愈乳腺癌。因此，识别促进和支持乳腺癌转移的因素对于理解如何靶向这一过程至关重要。激素上调的neu相关激酶（HUNK）是与蔗糖非发酵-1（Snf-1）/5'腺苷单磷酸活化蛋白激酶（AMPK）激酶家族相关的丝氨酸/苏氨酸蛋白激酶。已经发现HUNK在乳腺癌转移中起作用。然而，相互矛盾的报道表明HUNK既是转移促进因素，又是抑制因素。我们小组最近提供的证据支持了HUNK是一种转移促进因子的结论，表明HUNK通过EGFR的磷酸化调节乳腺癌转移。在这里，我们总结了我们的研究结果，并讨论了它们对乳腺癌中HUNK的药理学靶向的影响。
Once metastatic disease has occurred, there is no cure for breast cancer. Consequently, identifying factors that promote and support breast cancer metastasis is critical for understanding how to pharmacologically target this process. Hormonally up-regulated neu-associated kinase (HUNK) is a serine/threonine protein kinase related to the sucrose non-fermenting-1 (Snf-1)/5' adenosine monophosphate-activated protein kinase (AMPK) family of kinases. HUNK has been found to play a role in breast cancer metastasis. However, conflicting reports indicate HUNK is a metastasis promoting factor as well as an inhibiting factor. Our group recently provided evidence that supports the conclusion that HUNK is a metastasis promoting factor by showing that HUNK regulates breast cancer metastasis through phosphorylation of EGFR. Here, we summarize our findings and discuss their implications toward pharmacological targeting of HUNK in breast cancer.