Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues
Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues
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DOI：
10.1039/c1cc11465d
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Anraku, Yasutaka;Kishimura, Akihiro;Kataoka, Kazunori
纳米载体在靶组织中的选择性分布是药物递送中的一个重要问题。通过使用尺寸可调的聚离子复合物中空囊泡（PICsome）作为标尺来确定区分对正常组织和肿瘤组织的渗透性的纳米载体的临界尺寸（类似于150 nm）。
Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (similar to 150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.