Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse
Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse
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DOI：
10.1016/j.gep.2008.10.004
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发表时间：
2009-02-01
影响因子：
1.2
通讯作者：
Gruss, Peter
中科院分区：
文献类型：
--
作者：
Vogel, Tanja;Gruss, Peter
白血病相关 AF9/MLL73 突变与癫痫和共济失调等神经发育疾病有关。这项研究首次表明，小鼠Af9在多种中枢神经系统结构中转录，包括大脑皮层的室下区（SVZ）、海马、小脑皮质、隔膜和各种丘脑结构、脉络丛以及中脑/后脑边界。 Af9 在 SVZ 中的表达与 Svet1、Cux2 重叠，部分与 Tbr2 重叠，将其活性限制在 SVZ 的神经源性区室中。与 Svet1 和 Cux2 表达相反，Af9 转录不仅限于上层神经元，而且存在于整个皮质板中。作为参与表观遗传 DNA 修饰的相互作用蛋白的广泛网络的一部分，我们可以显示 Af9 与 Af4/Aff1 和 Fmr2/Aff2（也与神经发育疾病相关的两个基因）以及高度同源的 Enl 的重叠表达。 (C) 2008 Elsevier B.V. 保留所有权利。
Mutations of leukaemia associated AF9/MLL73 are implicated in neurodevelopmental diseases such as epilepsia and ataxia. This study shows for the first time, that murine Af9 is transcribed in various CNS structures including the subventricular zone (SVZ) of the cerebral cortex, hippocampus, cerebellar cortex, septum and Various thalamic structures, the choroid plexus, and the midbrain/hindbrain boundary. Expression of Af9 in the SVZ overlaps with Svet1, Cux2, and partially with Tbr2, confining its activity to the neurogenic compartment of the SVZ. In contrast to Svet1 and Cux2 expression, Af9 transcription is not limited to upper layer neurons but is found in the entire cortical plate. As part of an extensive network of interacting proteins involved in epigenetic DNA modification, we Could show overlapping expression of Af9 with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl. (C) 2008 Elsevier B.V. All rights reserved.