Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin β is the true human homologue of rat thymosin β15
Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin β is the true human homologue of rat thymosin β15
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DOI：
10.1016/j.febslet.2007.09.003
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发表时间：
2007-10-16
期刊：
影响因子：
3.5
通讯作者：
Van Troys, M.
中科院分区：
文献类型：
--
作者：
Dhaese, S.;Jonckheere, V.;Van Troys, M.
据报道，一种与大鼠胸腺素β(TB)15序列相同的多肽在人类前列腺癌中上调。然而，在这份报告中，我们提供的证据表明，最初在人类神经母细胞瘤中发现的TbNb是唯一在人类前列腺癌中上调的TbNb亚型，并且Tb15序列在本文中不存在。此外，我们还证明了与Tb4相比，人TbNB对肌动蛋白具有更高的亲和力，并促进细胞迁移。结合起来，这一实验验证了TbNb是人类有机体中大鼠Tb15的功能同源物，并澄清了目前人类结核病家族的组成。(C)2007年欧洲生化学会联合会。爱思唯尔出版，版权所有。
A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.