Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances
Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances
复制标题
DOI：
10.1017/s0029665115004231
复制
发表时间：
2016-02-01
影响因子：
7
通讯作者：
Diaz, Ruben
中科院分区：
文献类型：
--
作者：
Jimenez-Chillaron, Josep C.;Ramon-Krauel, Marta;Diaz, Ruben
当今世界，包括肥胖、胰岛素抵抗和2型糖尿病在内的慢性代谢性疾病的患病率正以前所未有的速度上升。T2D的发病机制包括遗传和环境因素，如能量摄入过多和缺乏运动。最近有研究表明，早期发育阶段的环境因素，包括宫内和新生儿时期，可能在个体易患T2D中起主要作用。此外，一些研究表明，这种早期的环境条件甚至可能会增加后代的疾病风险。在这篇综述中，我们总结了最近的数据，描述了父母在发育过程中的营养如何增加后代患糖尿病的风险。我们还讨论了代谢性疾病跨代遗传的潜在机制，特别强调了表观遗传机制。
In today's world, there is an unprecedented rise in the prevalence of chronic metabolic diseases, including obesity, insulin resistance and type 2 diabetes (T2D). The pathogenesis of T2D includes both genetic and environmental factors, such as excessive energy intake and physical inactivity. It has recently been suggested that environmental factors experienced during early stages of development, including the intrauterine and neonatal periods, might play a major role in predisposing individuals to T2D. Furthermore, several studies have shown that such early environmental conditions might even contribute to disease risk in further generations. In this review, we summarise recent data describing how parental nutrition during development increases the risk of diabetes in the offspring. We also discuss the potential mechanisms underlying transgenerational inheritance of metabolic disease, with particular emphasis on epigenetic mechanisms.