Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low-Molecular Weight Gelators
Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low-Molecular Weight Gelators
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DOI：
10.1002/anie.201405098
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发表时间：
2014-11-10
影响因子：
16.6
通讯作者：
Smith, David K.
中科院分区：
文献类型：
--
作者：
Cornwell, Daniel J.;Okesola, Babatunde O.;Smith, David K.
据报道，一种简单的图案化多域凝胶方法，结合了 pH 响应型低分子量凝胶剂 (LMWG) 和光诱导聚合物凝胶剂 (PG)。使用 SEM（扫描电子显微镜）、NMR 光谱和 CD，我们证明 LMWG 网络的自组装发生在 PG 网络存在的情况下，但 PG 对 LMWG 组装动力学和形态有影响。在光照射过程中使用掩模可以形成 PG 网络的图案；我们将所得系统定义为由 LMWG 组成的多域 gelone 域，而图案化区域包含 LMWG 和 PG 网络。不同的域在小分子扩散方面具有不同的特性，并且两种胶凝剂网络都可以控制扩散速率以提供能够控制释放的系统。此类材料未来可能应用于药物释放的多动力控制，或作为定向组织工程的图案化支架。
A simple approach to a patterned multidomain gel is reported, combining a pH-responsive low-molecular-weight gelator (LMWG) and a photoinducible polymer gelator (PG). Using SEM (scanning electron microscopy), NMR spectroscopy, and CD, we demonstrate that self-assembly of the LMWG network occurs in the presence of the PG network, but that the PG has an influence on LMWG assembly kinetics and morphology. The application of a mask during photoirradiation allows patterning of the PG network; we define the resulting system as a multidomain gelone domain consists of a LMWG, whereas the patterned region contains both LMWG and PG networks. The different domains have different properties with regard to diffusion of small molecules, and both gelator networks can control diffusion rates to give systems capable of controlled release. Such materials may have future applications in multikinetic control of drug release, or as patterned scaffolds for directed tissue engineering.