Biomaterials for vascular tissue engineering.
Biomaterials for vascular tissue engineering.
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DOI：
10.2217/rme.09.77
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发表时间：
2010-01
影响因子：
2.7
通讯作者：
Chaikof EL
中科院分区：
文献类型：
--
作者：
Ravi S;Chaikof EL
心血管疾病是美国死亡的主要原因。用于旁路移植术的健康自体血管的有限可用性导致了人工血管导管的制造。虽然合成聚合物已被广泛研究作为血管工程的替代品，但它们无法满足血液-材料界面的生物学挑战。已经出现了各种组织工程策略来解决这些缺陷并增加血管移植物的长期通畅性。血管细胞种植支架和设计用于原位动脉再生的生物活性聚合物已经取得了可喜的成果。本文介绍了生物材料设计的进展，以产生合适的材料，不仅匹配天然血管系统的机械性能，但也促进细胞生长，促进细胞外基质的生产和抑制血栓形成。
Cardiovascular disease is the leading cause of mortality in the USA. The limited availability of healthy autologous vessels for bypass grafting procedures has led to the fabrication of prosthetic vascular conduits. While synthetic polymers have been extensively studied as substitutes in vascular engineering, they fall short of meeting the biological challenges at the blood–material interface. Various tissue engineering strategies have emerged to address these flaws and increase long-term patency of vascular grafts. Vascular cell seeding of scaffolds and the design of bioactive polymers for in situ arterial regeneration have yielded promising results. This article describes the advances made in biomaterials design to generate suitable materials that not only match the mechanical properties of native vasculature, but also promote cell growth, facilitate extracellular matrix production and inhibit thrombogenicity.