H2FPEF Score for the Prediction of Exercise Intolerance and Abnormal Hemodynamics in Japanese - Evaluation by Exercise Stress Echocardiography Combined With Cardiopulmonary Exercise Testing -
H2FPEF Score for the Prediction of Exercise Intolerance and Abnormal Hemodynamics in Japanese - Evaluation by Exercise Stress Echocardiography Combined With Cardiopulmonary Exercise Testing -
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DOI：
10.1253/circj.cj-19-0699
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发表时间：
2019-12-01
影响因子：
3.3
通讯作者：
Kihara, Yasuki
中科院分区：
文献类型：
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作者：
Takahari, Kosuke;Hidaka, Takayuki;Kihara, Yasuki
工作背景：H2 FPEF评分和诺模图评分均由简单的临床参数组成，可辅助诊断射血分数保留（HFpEF）和劳力性呼吸困难的“早期”心力衰竭，但其在日本的应用尚不清楚。我们试图通过运动负荷超声心动图（ESE）结合心肺运动试验（CPET）研究这些评分与运动反应之间的相关性，包括峰值摄氧量（V/dotO（2））、肺动脉收缩压（PASP）、舒张早期二尖瓣血流速度与舒张早期二尖瓣环速度的比值（E/e '）和每搏输出量（SV）。方法和结果：在这项单中心、回顾性横断面研究中，计算了139例接受ESE联合CPET的患者的H2 FPEF评分和诺模图评分。运动峰值时，PASP（r = 0.23，r=0.29）、SV（r=-0.32，r =-0.19）与dotO 2（r=-0.48，r =-0.44）上的峰值（V）呈负相关。列线图评分与E/e'相关（r=0.24）。运动不耐受的患病率（预测峰值（V）相对于dotO（2）的百分比）
Background: Both the H2FPEF-score and nomogram-score, which consist of simple clinical parameters, can assist indiagnosing "early" heart failure with preserved ejection fraction (HFpEF) and only exertional dyspnea, but their these usefulness in Japanese remains unclear. We sought to investigate the correlation between these scores and exercise response, including the peak oxygen uptake ((V) over dotO(2)), the pulmonary artery systolic pressure (PASP), the ratio of early diastolic transmitral flow velocity to early diastolic mitral annular velocity (E/e') and stroke volume (SV) using exercise stress echocardiography (ESE) combined with cardiopulmonary exercise testing (CPET). Methods andResults: In this single-center, retrospective cross-sectional study the H2FPEF-score and nomogram-score were calculated in a total of 139 patients who underwent ESE combined with CPET. The scores correlated with peak (V) over dotO(2) (r=-0.48, r=-0.44), PASP (r=0.23, r=0.29) and SV (r=-0.32, r=-0.19) at peak exercise. The nomogram-score correlated with E/e' (r=0.24). The prevalence of exercise intolerance (percent predicted peak (V) over dotO(2)