The functionalization of multi-walled carbon nanotubes by in situ deposition of hydroxyapatite
The functionalization of multi-walled carbon nanotubes by in situ deposition of hydroxyapatite
复制标题
羟基磷灰石原位沉积多壁碳纳米管的功能化
DOI：
10.1016/j.biomaterials.2010.03.012
复制
发表时间：
2010-07-01
期刊：
影响因子：
14
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Xiao, Yu;Gong, Tao;Zhou, Shaobing
通过原位沉积羟基磷灰石(HA)对多壁碳纳米管(MWNTs)进行功能化处理，以提高其亲水性和生物相容性。首先，我们制备了两种预官能化多壁碳纳米管：酸氧化多壁碳纳米管和聚乙二醇共价修饰多壁碳纳米管。在离子浓度分别为2倍、5倍和10倍的模拟体液中，研究了酸氧化时间、预磷酸化和聚乙二醇化对羟基磷灰石原位生长的影响，结果表明，酸氧化时间、预磷酸化和聚乙二醇化对羟基磷灰石晶体的生长都有积极的影响，尤其是聚乙二醇化在沉积过程中起着关键作用。最后，通过四甲基偶氮唑盐(MU)实验评价了其细胞毒性，结果表明聚乙二醇化的羟基磷灰石包裹的多壁碳纳米管具有最好的生物相容性。(C)2010爱思唯尔有限公司。保留所有权利。
A simple and effective approach was introduced to functionalize multi-walled carbon nanotubes (MWNTs) by in situ deposition of hydroxyapatite (HA) to improve their hydrophilicity and biocompatibility. Firstly, we prepared two types of pre-functionalized MWNTs: acid-oxidated MWNTs and covalently modified MWNTs by poly (ethylene glycol) (PEG). The influences of the acid-oxidated time, pre-phosphorylation, and PEGylation of MWNTs on in situ growth of HA were further investigated in simulated body fluid (SBF) with ionic concentration: 2, 5 and 10 times, respectively, at 37 degrees C for 24 h. The results exhibited that all these factors have positive effects on the HA crystals growth, especially the PEGylation of MWNTs plays a key role during the deposition. Finally, the methyl thiazolyl tetrazolium (MU) assay was performed to evaluate their cytotoxicity, which showed that the PEGylated MWNTs wrapped by HA crystals have the best biocompatibility. (C) 2010 Elsevier Ltd. All rights reserved.