Control of metastatic progression by microRNA regulatory networks.
Control of metastatic progression by microRNA regulatory networks.
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DOI：
10.1038/ncb2769
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发表时间：
2013-06
影响因子：
21.3
通讯作者：
Tavazoie SF
中科院分区：
文献类型：
--
作者：
Pencheva N;Tavazoie SF
异常的 microRNA (miRNA) 表达是人类恶性肿瘤的一个决定性特征。特定的 miRNA 已被确定为转移进展的启动子或抑制子。这些 miRNA 通过转移基因途径的发散或聚合调节来控制转移。一些 miRNA 调控网络控制细胞自主癌症表型，而另一些调控网络转移微环境的细胞外在组成。使用小RNA作为转移的分子和细胞基础的探针有望鉴定潜在治疗干预的候选基因。
Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. These miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autonomous cancer phenotypes, while others modulate the cell-extrinsic composition of the metastatic microenvironment. The use of small RNAs as probes into the molecular and cellular underpinnings of metastasis holds promise for the identification of candidate genes for potential therapeutic intervention.