Effects of MRI abnormalities on WAIS‐R performance in solvent abusers
Effects of MRI abnormalities on WAIS‐R performance in solvent abusers
复制标题
MRI 异常对溶剂滥用者 WAIS-R 表现的影响
DOI：
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发表时间：
1997
影响因子：
3.5
通讯作者：
Takeyuki Sato
中科院分区：
文献类型：
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作者：
N. Yamanouchi;S. Okada;K. Kodama;T. Sakamoto;H. Sekine;S. Hirai;A. Murakami;N. Komatsu;Takeyuki Sato
目的-利用磁共振成像作为脑损伤指标，阐明慢性溶剂滥用如何影响认知功能。材料和方法‐对25名慢性溶剂滥用者进行了定量神经测量和修订的韦氏成人智力量表的磁共振成像。结果‐有白质改变的滥用者（n=10）表现出较低的智商（P< 0.05），特别是在数字符号测试中（P<0.01）。脑桥萎缩严重程度与PIQ呈显著相关（r=0.60， P<0.01）。结论-这些数据表明，溶剂滥用导致反映认知和精细运动功能障碍的测试成绩下降，白质变化和脑桥萎缩可能在这种下降中起一定作用。
Objective ‐ To clarify how chronic solvent abuse affects cognitive function using magnetic resonance imaging as an index of brain damage. Material and methods ‐ A total of 25 chronic solvent abusers underwent magnetic resonance imaging with quantitative neurometry and Wechsler Adult Intelligence Scales revised. Results ‐ The abusers with white matter change (n=10) showed significantly (P < 0.05) lower performance IQ, especially in Digit Symbol subtest (P<0.01). Also, the severity of pontine atrophy was significantly correlated with PIQ (r=0.60, P<0.01). Conclusions ‐ These data indicate that solvent abuse causes the decline in the test performance reflecting cognitive and fine motor dysfunction and that white matter changes and pontine atrophy may have some roles in this decline.