Novel therapeutic strategies for patients with triple-negative breast cancer.
Novel therapeutic strategies for patients with triple-negative breast cancer.
复制标题
三阴性乳腺癌患者的新治疗策略
DOI：
10.2147/ott.s105716
复制
发表时间：
2016
影响因子：
4
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Zhang JF;Liu J;Wang Y;Zhang B
三阴性乳腺癌（TNBC）代表了一组非常异质性的乳腺疾病。目前，TNBC的治疗主要是化疗，因为没有有效的特异性靶向药物被批准用于治疗TNBC。尽管最初对化疗有反应，但耐药性频繁且迅速发展，转移性TNBC预后不良。因此，迫切需要新的有针对性的战略。本文讨论了针对TNBC探索的靶向药物的最新进展，旨在提供新的治疗策略，这些策略可能有助于未来设计个性化治疗方法，并为进一步研究TNBC提供基础。
Triple-negative breast cancer (TNBC) represents a very heterogeneous group of breast diseases. Currently, the backbone of therapy for TNBC is mainly chemotherapy as there are no effective specific targeted agents approved to treat TNBC. Despite initial responses to chemotherapy, resistance frequently and rapidly develops and metastatic TNBC has a poor prognosis. Therefore, new targeted strategies are, accordingly, urgently needed. This article discusses the recent developments in targeted agents explored for TNBC, aiming to offer novel therapeutic strategies that can potentially assist in designing personalized therapeutics in the future as well as provide the basis for further research in an attempt to target TNBC.