Postprandial lipemia: The origin of an early peak studied by specific dietary fatty acid intake during sequential meals
Postprandial lipemia: The origin of an early peak studied by specific dietary fatty acid intake during sequential meals
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DOI：
10.1093/ajcn/63.1.36
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发表时间：
1996-01-01
影响因子：
7.1
通讯作者：
Frayn, KN
中科院分区：
文献类型：
--
作者：
Fielding, BA;Callow, J;Frayn, KN
先前的研究已经注意到血浆三酰甘油浓度在餐后早期出现峰值，特别是当连续进餐时。我们检验了前一餐中的脂肪导致这种早期餐后脂血症的假设。我们研究了在早餐后5小时内摄入含有61 g脂肪的午餐的影响，早餐含有54 g脂肪。第一餐中的主要脂肪酸（以总脂肪酸的重量%表示）为18：2（亚油酸），68%和18：1（油酸），19%。第二餐的主要脂肪酸为18：1（75%）和18：2（8%）。午餐后，发现乳糜微粒三酰甘油的早期峰值（在50-60分钟）含有大比例的18：2，这是第一餐的主要成分，而在稍后的时间点，乳糜微粒三酰甘油脂肪酸谱更接近于第二餐。在三名受试者中进行的对照研究显示，当午餐被省略或第一餐脂肪含量低时，血浆和乳糜微粒三酰甘油浓度的早期峰值完全不存在。血浆非酯化脂肪酸谱在50-60 min时也显示了18：2的相应峰，这可能代表脂肪组织脂蛋白脂肪酶水解乳糜微粒三酰甘油产生的脂肪酸释放到血浆中。
Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentration, particularly when successive meals have been consumed. We tested the hypothesis that fat from a previous meal contributes to this early postprandial lipemia. We investigated the effect of consuming a lunch containing 61 g fat 5 h after a breakfast containing 54 g fat. The predominant fatty acids in the first meal, expressed as % by wt of total fatty acids, were 18:2 (linoleic acid), 68%, and 18:1 (oleic acid), 19%. The main fatty acids in the second meal were 18:1 (75%) and 18:2 (8%). After lunch, the early peak (at 50-60 min) in chylomicron triacylglycerol was found to contain a large proportion of 18:2, the main constituent of the first meal, whereas at later time points the chylomicron triacylglycerol fatty acid profile more closely resembled that of the second meal. Control studies in three subjects showed the complete absence of the early peaks in plasma and chylomicron triacylglycerol concentrations when either the lunch was omitted or the first meal was low in fat. The plasma nonesterified fatty acid profile also showed a corresponding peak in 18:2 at 50-60 min, which may represent the release into the plasma of fatty acids arising from the hydrolysis of chylomicron triacylglycerol by adipose tissue lipoprotein lipase.