Ecological influences on the behaviour and fertility of malaria parasites.
Ecological influences on the behaviour and fertility of malaria parasites.
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DOI：
10.1186/s12936-016-1271-0
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发表时间：
2016-04-18
期刊：
影响因子：
3
通讯作者：
Reece SE
中科院分区：
文献类型：
--
作者：
Carter LM;Pollitt LC;Wilson LG;Reece SE
蚊子的有性生殖对于疟疾寄生虫的传播至关重要，也是阻断传播干预措施的主要目标。雄性配子需要在蚊子血餐的挑战性环境中定位和受精雌性，但对雄性配子的生态和行为知之甚少。在这里，一系列的实验探讨了在交配过程中所经历的化学和物理环境的某些方面如何影响雄性配子的产生、运动和生育能力。具体而言，这些数据证实：（a）当被认为在自然界中触发配子分化的化合物家族（色氨酸代谢物）诱导时，雄性配子发生的速率不同;（B）配子发生和交配成功之间的复杂关系存在于寄生虫物种中。此外，数据显示，（c）与红细胞大小相同的微粒会对交配成功产生负面影响;（d）雄性配子可能会被雌性配子吸引，而不是随机游动。了解疟疾寄生虫的交配生态学，可以提供阻断传播的新方法，并解释对不同种类蚊子媒介的适应。本文的在线版本（doi：10.1186/s12936-016-1271-0）包含补充材料，可供授权用户使用。
Sexual reproduction in the mosquito is essential for the transmission of malaria parasites and a major target for transmission-blocking interventions. Male gametes need to locate and fertilize females in the challenging environment of the mosquito blood meal, but remarkably little is known about the ecology and behaviour of male gametes. Here, a series of experiments explores how some aspects of the chemical and physical environment experienced during mating impacts upon the production, motility, and fertility of male gametes. Specifically, the data confirm that: (a) rates of male gametogenesis vary when induced by the family of compounds (tryptophan metabolites) thought to trigger gamete differentiation in nature; and (b) complex relationships between gametogenesis and mating success exist across parasite species. In addition, the data reveal that (c) microparticles of the same size as red blood cells negatively affect mating success; and (d) instead of swimming in random directions, male gametes may be attracted by female gametes. Understanding the mating ecology of malaria parasites, may offer novel approaches for blocking transmission and explain adaptation to different species of mosquito vectors. The online version of this article (doi:10.1186/s12936-016-1271-0) contains supplementary material, which is available to authorized users.