Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution
Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution
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DOI：
10.1126/science.1060310
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发表时间：
2001-07-06
期刊：
影响因子：
56.9
通讯作者：
Stubbs, L
中科院分区：
文献类型：
--
作者：
Dehal, P;Predki, P;Stubbs, L
为了阐明这两个基因组的功能和进化历史，我们对与人类 19 号染色体相关的小鼠 DNA 进行了测序。比较序列比对为假设的基因提供了确凿的证据，并确定了其他预测方法遗漏的外显子、调控元件和候选基因。染色体范围的比较揭示了单拷贝 HSA19 基因（在小鼠中绝大多数保守）和串联熟悉簇中的基因之间的差异，这些基因在两个物种之间的数量、编码能力和组织方面存在巨大差异。最后，我们对所有 15 个进化重排的断点进行了测序，提供了驱动哺乳动物染色体进化的力量的观点。
To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familiar clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.