Functional-neuroanatomic correlates of recollection: Implications for models of recognition memory
Functional-neuroanatomic correlates of recollection: Implications for models of recognition memory
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DOI：
10.1523/jneurosci.0624-04.2004
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发表时间：
2004-04-28
影响因子：
5.3
通讯作者：
Wagner, AD
中科院分区：
文献类型：
--
作者：
Kahn, I;Davachi, L;Wagner, AD
识别决策可以基于熟悉度，即以前遇到过的物品的感觉（物品记忆），以及回忆，即有意识地恢复以前遇到过的物品的上下文信息（例如，源记忆）。具有回忆的识别被认为依赖于多种机制，包括指导检索的前额叶“控制”过程和重新激活编码时存在的后皮层表征的重述机制。然而，关于前额叶对回忆的贡献的确切性质和对真实性回忆的复述的选择性，仍然存在不确定性。当前的事件相关功能磁共振成像研究试图检查显示“旧-新”效应的区域是否支持对回忆成功或回忆尝试敏感的过程，以及新皮层表征的再现是否在真实性回忆和错误识别（即假警报）期间出现，或者错误识别是否类似于基于熟悉的反应。结果显示，在试图回忆之前的上下文（源）细节时，多个左前额叶皮质区域参与其中，而不管要回忆的细节的性质和源回忆的结果（成功或不成功）。重述效应在对编码任务敏感的区域被观察到，这表明真实性回忆需要在编码过程中出现的过程或表征的重新激活。重要的是，与主要的识别记忆模型相比，假警报似乎也部分基于回忆，这是通过虚假重述效应揭示的。考虑了识别的神经和认知模型的含义。
Recognition decisions can be based on familiarity, the sense that an item was encountered previously (item memory), and on recollection, the conscious recovery of contextual information surrounding a previous encounter with the item (e. g., source memory). Recognition with recollection is thought to depend on multiple mechanisms, including prefrontal "control" processes that guide retrieval and recapitulation mechanisms that reactivate posterior neocortical representations that were present at encoding. However, uncertainty remains regarding the precise nature of prefrontal contributions to recollection and the selectivity of recapitulation to veridical recollection. The present event-related functional magnetic resonance imaging study sought to examine whether regions showing "old-new" effects support processes sensitive to recollection success or recollection attempt and whether recapitulation of neocortical representations emerge during veridical recollection as well as during false recognition (i.e., false alarms) or whether false recognition resembles familiarity-based responding. Results revealed that multiple left prefrontal cortical regions were engaged during attempts to recollect previous contextual (source) details, regardless of the nature of the to-be-recollected details and of source recollection outcome (successful vs unsuccessful). Recapitulation effects were observed in regions sensitive to the encoding task, suggesting that veridical recollection entails the reactivation of processes or representations present during encoding. Importantly, in contrast to leading models of recognition memory, false alarms also appeared to be based partially on recollection, as revealed through false recapitulation effects. Implications for neural and cognitive models of recognition are considered.