Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy
Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy
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DOI：
10.1038/s41390-019-0433-5
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发表时间：
2019-09-01
影响因子：
3.6
通讯作者：
Friedman, Jennifer F.
中科院分区：
文献类型：
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作者：
Abioye, Ajibola, I;McDonald, Emily A.;Friedman, Jennifer F.
背景：我们评估了母亲贫血的病因与整个婴儿期铁状况之间的关联。方法：使用了一项旨在检查妊娠期间吡喹酮治疗的研究样本（n = 359）。所有女性均感染血吸虫病，并在妊娠 16 +/- 2 周时随机接受吡喹酮或安慰剂治疗。测量母体和婴儿血液中的血红蛋白、血清铁蛋白 (SF)、可溶性转铁蛋白受体 (sTfR)、铁调素、C 反应蛋白和白细胞介素 6。评估了母亲吡喹酮治疗与贫血病因和婴儿铁状况之间的关系。结果：母亲缺铁性贫血与 6 个月大婴儿贫血风险增加相关。妊娠期间循环铁调素（可能是缺铁的标志）水平最低的母亲所生的婴儿，其 sTfR:SF 水平较高，血红蛋白水平较低，尤其是在 12 个月大时。母亲非缺铁性贫血 (NIDA) 不会影响婴儿贫血风险或铁状况。母亲的血吸虫病治疗对婴儿的血液学状态没有影响。结论：母亲缺铁性贫血与婴儿后期贫血或缺铁的风险增加相关。我们没有观察到母亲 NIDA 与婴儿期缺铁风险增加之间存在关联。
BACKGROUND: We evaluated the association between etiology of maternal anemia and iron status throughout infancy.METHODS: Samples from a study designed to examine Praziquantel treatment during pregnancy were used (n = 359). All women were infected with schistosomiasis and randomized to Praziquantel or placebo at 16 +/- 2 weeks' gestation. Hemoglobin, serum ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, C-reactive protein, and interleukin-6 were measured in maternal and infant blood. The relationship between both maternal Praziquantel treatment and etiology of anemia and infant iron status was evaluated.RESULTS: Maternal iron-deficiency anemia was associated with increased risk of infant anemia at 6 months of age. Infants of mothers with the lowest levels of circulating hepcidin during gestation, likely a marker for iron deficiency, had higher sTfR:SF levels and lower hemoglobin levels, particularly at 12 months of age. Maternal non-iron-deficiency anemia (NIDA) did not impact infant anemia risk or iron status. Maternal treatment for schistosomiasis had no effect on infant hematologic status.CONCLUSIONS: Maternal iron deficiency anemia was associated with an increased risk for anemia or iron deficiency during late infancy. We did not observe an association between maternal NIDA and increased risk for iron deficiency during infancy.