Ultrastructure of well-differentiated adenocarcinoma of the gallbladder.
Ultrastructure of well-differentiated adenocarcinoma of the gallbladder.
复制标题
胆囊高分化腺癌的超微结构。
DOI：
10.3109/01913129109021302
复制
发表时间：
1991
影响因子：
1
通讯作者：
T. Makino
中科院分区：
文献类型：
--
作者：
A. Koga;S. Momii;M. Eguchi;T. Makino
通过扫描和透射电镜观察胆囊4种高分化腺癌的超微结构，并与同一标本中的非肿瘤性粘膜和胆囊结石胆囊粘膜的超微结构进行比较。扫描电镜观察肿瘤细胞柱状细胞规则排列严重紊乱。它们的形状和大小奇特，覆盖着不发达、分布不规则的多形性微绒毛。对照样本中没有出现这样的发现。透射电镜观察肿瘤细胞呈现多形性微绒毛、发达的细胞质细胞器、多种粘液颗粒、丰富的溶酶体和核变化。这些发现表明肿瘤细胞的分泌和代谢活性增加。杯状细胞、潘氏样细胞和内分泌细胞分散在两个癌中。这些细胞也在癌标本的非肿瘤性粘膜中被发现，但当存在胆石症时，这些细胞在粘膜中很少见。
The ultrastructure of four well-differentiated adenocarcinomas of the gallbladder was investigated by scanning and transmission electron microscopy and compared with the ultrastructure of nonneoplastic mucosa in the same specimens and of the mucosa of gallbladders with gallstones. The tumor cells seen by scanning electron microscopy had severe disorganization of the regular arrangement of columnar cells. They were bizarre in shape and size and were covered with less developed pleomorphic microvilli that were irregularly distributed. No such findings appeared in the control specimens. The tumor cells seen by transmission electron microscopy exhibited pleomorphic microvilli, well-developed cytoplasmic organelles, various mucus granules, abundant lysosomes, and nuclear changes. These findings suggest increased secretory and metabolic activity in the tumor cells. Gobletlike cells, Paneth-like cells, and endocrine cells were scattered in two of the carcinomas. These cells were also noted in the nonneoplastic mucosa of the carcinoma specimens but were rare in the mucosa when cholelithiasis was present.