Relation between cardiovascular disease risk factors and epicardial adipose tissue density on cardiac computed tomography in patients at high risk of cardiovascular events
Relation between cardiovascular disease risk factors and epicardial adipose tissue density on cardiac computed tomography in patients at high risk of cardiovascular events
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DOI：
10.1177/2047487316679524
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发表时间：
2017-04-01
影响因子：
8.3
通讯作者：
Visseren, Frank L. J.
中科院分区：
文献类型：
--
作者：
Franssens, Bas T.;Nathoe, Hendrik M.;Visseren, Frank L. J.
背景资料：除了心外膜脂肪组织体积外，心外膜脂肪组织的放射密度还可以提供心血管风险的信息。本研究的目的是量化的心血管危险因素和心外膜脂肪组织的放射密度的患者在高风险的心血管diseases.Design：这是一个横断面研究在140例患者在高风险的心血管diseases.Methods：患者的继发性表现动脉疾病（SMART）队列研究被邀请接受心脏计算机断层扫描血管造影。半自动定量心外膜脂肪组织的放射密度（Hounsfield单位; HU）和体积（cm（3））。采用多元线性回归分析心血管危险因素与心外膜脂肪放射密度的关系。与心外膜脂肪组织密度最密切相关的心血管危险因素是性别、体重指数和内脏脂肪，较低的脂肪组织衰减为3.5 HU（95%置信区间（CI）2.0-5.0 HU），女性，1.6 HU（95% CI 0.2-2.9 HU）体重指数>25 kg/m2和1.3 HU（95%CI 0.6-2.0 HU），内脏脂肪量高出一个标准差，校正年龄、性别、冠状动脉旁路移植术史和心外膜脂肪组织体积。低心外膜脂肪组织CT衰减与心血管疾病高风险患者的不良心血管风险因素特征相关，与心外膜脂肪组织体积和腰围无关。这些发现支持心外膜脂肪组织放射密度作为心血管风险的有效生物标志物的潜在作用。脂肪组织放射密度可能是一个比心外膜脂肪组织体积更敏感的指标，可以用来研究心外膜脂肪组织对冠状动脉粥样硬化疾病过程的贡献。
Background: The radiodensity of epicardial adipose tissue may provide information on cardiovascular risk in addition to epicardial adipose tissue volume. The aim of this study was to quantify the relation between cardiovascular risk factors and the radiodensity of epicardial adipose tissue in patients at high risk of cardiovascular disease.Design: This was a cross-sectional study in 140 patients at high risk of cardiovascular disease.Methods: Patients from the Secondary Manifestations of ARTerial disease (SMART) cohort study were invited to undergo cardiac computed tomography angiography. The radiodensity (in Hounsfield units; HU) and volume (in cm(3)) of epicardial adipose tissue were quantified semi-automatically. Multivariable linear regression was used to quantify the relation between cardiovascular risk factors and the radiodensity of epicardial adipose tissue.Results: The cardiovascular risk factors most strongly associated with epicardial adipose tissue density were sex, body mass index and visceral fat, with a lower adipose tissue attenuation of 3.5 HU (95% confidence interval (CI) 2.0-5.0 HU) for female sex, 1.6 HU (95% CI 0.2-2.9 HU) for body mass index >25 kg/m(2) and 1.3 HU (95% CI 0.6-2.0 HU) for a one standard deviation higher quantity of visceral fat, adjusted for age, sex, coronary artery bypass graft history and epicardial adipose tissue volume.Conclusion: Low epicardial adipose tissue computed tomography attenuation is associated with an adverse cardiovascular risk factor profile in patients at high risk of cardiovascular disease, independent of the volume of epicardial adipose tissue and waist circumference. These findings support the potential role for epicardial adipose tissue radiodensity as a valid biomarker of cardiovascular risk. Adipose tissue radiodensity may be a more sensitive marker than epicardial adipose tissue volume with which to study the contribution of epicardial adipose tissue to the coronary atheromatous disease process.