Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators.
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators.
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DOI：
10.1289/ehp.7767
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发表时间：
2005-06
影响因子：
10.4
通讯作者：
Verrier RL
中科院分区：
文献类型：
--
作者：
Dockery DW;Luttmann-Gibson H;Rich DQ;Link MS;Mittleman MA;Gold DR;Koutrakis P;Schwartz JD;Verrier RL
流行病学研究表明，心脏性猝死与颗粒物空气污染之间存在一致的联系。我们使用植入的室性快速性心律失常的心律转复除颤器(ICD)记录来评估空气污染作为这些潜在威胁生命事件的触发因素的作用。这项研究队列包括波士顿大都会地区203名使用ICD装置的心脏病患者，他们在1995至2002年间平均随访3.1年。几乎所有天都测量了细颗粒物质量和气态空气污染加上温度和相对湿度，并在部分天数测量了黑碳、硫酸盐和颗粒物数量。在患者的定期随访中(大约每3个月)下载ICD检测到的心律失常的日期、时间和心内电信号。室性快速性心律失常通过电生理学家的复习来确定。对季节、温度、相对湿度、一周中的某一天、患者和最近一次的心律失常进行调整后，用Logistic回归估计与空气污染相关的室性心律失常的风险。我们发现，对于所有考虑的空气污染物，平均暴露2天会增加室性心律失常的风险，尽管这些联系在统计学上并不显著。我们发现，空气污染与室性心律失常之间存在统计学意义上的相关性，这些事件发生在既往心律失常的3天内。室性快速性心律失常与细小颗粒物、一氧化碳、二氧化氮和黑碳的相关性提示与机动车污染物有关。与硫酸盐的关联表明，与固定的化石燃料燃烧来源有关。
Epidemiologic studies have demonstrated a consistent link between sudden cardiac deaths and particulate air pollution. We used implanted cardioverter defibrillator (ICD) records of ventricular tachyarrhythmias to assess the role of air pollution as a trigger of these potentially life-threatening events. The study cohort consisted of 203 cardiac patients with ICD devices in the Boston metropolitan area who were followed for an average of 3.1 years between 1995 and 2002. Fine particle mass and gaseous air pollution plus temperature and relative humidity were measured on almost all days, and black carbon, sulfate, and particle number on a subset of days. Date, time, and intracardiac electrograms of ICD-detected arrhythmias were downloaded at the patients’ regular follow-up visits (about every 3 months). Ventricular tachyarrhythmias were identified by electrophysiologist review. Risk of ventricular arrhythmias associated with air pollution was estimated with logistic regression, adjusting for season, temperature, relative humidity, day of the week, patient, and a recent prior arrhythmia. We found increased risks of ventricular arrhythmias associated with 2-day mean exposure for all air pollutants considered, although these associations were not statistically significant. We found statistically significant associations between air pollution and ventricular arrhythmias for episodes within 3 days of a previous arrhythmia. The associations of ventricular tachyarrhythmias with fine particle mass, carbon monoxide, nitrogen dioxide, and black carbon suggest a link with motor vehicle pollutants. The associations with sulfate suggest a link with stationary fossil fuel combustion sources.
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影响因子：
5.4
作者：
Schwartz, J
通讯作者：
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